乙肝患者血清TNF的含量与肝损伤程度及病毒复制的关系

Relationship among Serum Tumor Necrosis Factor Level, Liver Lesion and Viral Replication in Patients with Liver Diseases

目的 :研究乙肝患者血清中肿瘤坏死因子 (TNF)的含量变化及其与乙肝病毒 (HBV)复制的关系。方法 :各型肝炎患者 133例 ,对照组 30例 ,用放射免疫法检测血清TNF含量 ,同时检测肝功能和HBV -DNA ,HBeAg。结果 :急性肝炎、慢性肝炎轻度、慢性肝炎中度、慢性肝炎重度、肝炎后肝硬化、肝癌患者血清TNF含量 ( x±s)分别为 :(1.17± 1.2 4 )ng/mL、(0 .5 5± 0 .35 )ng/mL、(0 .72± 0 .2 5 )ng/mL、(0 .73± 0 .2 8)ng/mL、(0 .88± 0 .30 )ng/mL和(0 96± 0 .36 )ng/mL明显高于对照组 (0 .2 9± 0 .18)ng/mL(P <0 .0 1)。HBV -DNA、HBeAg阳性患者血清TNF含量明显高于阴性患者 ,TNF与肝功能损害指标明显相关 (P <0 .0 5 )。结论 :TNF是肝细胞坏死的重要介质之一 。

Objective:To study the relationship between the change of the level of tumor necrosis factor (TNF) and Hepatitis B Virus replication in patients with liver diseases. Methods: Serum TNF,liver function indexes and HBV-DNA、HBeAg were measured in 133 patients with liver diseases and 30 healthy persons as normal control. Results: TNF level was (1.17±1.24)ng/mL in acute hepatitis,(0.55±0.35)ng/mL in mild chronic hepatitis,(0.72±0.25)ng/mL in moderate chronic hepatitis,(0.73±0.28)ng/mL in severe chronic hepatitis,(0.88±0 30) ng/mL in liver cirrhosis and (0.96±0.36)ng/mL in liver carcinoma. All significantly higher than those in control group(0.29±0.18)ng/mL,( P <0.01).The levels of TNF in patients with positive HBV-DNA and HBeAg were significantly higher than those with the negative. Serum TNF was positively correlated with the levels of liver function ( P <0.05). Conclusion: TNF is a very important medium of the liver cell necrosis. There are close relations among TNF and the degree of liver lesion and the HBV replication.