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组织芯片技术与肿瘤研究 被引量：3

Development and Application of Tissue Microarray Technology in Tumor Research
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摘要 本文对组织芯片的概念、分类、发展历史和在抗体筛选、蛋白表达、基因扩增、新基因的发现以及与基因芯片的结合等方面进行了综述 。 The concept,classification,history, current status of tissue microarray were reviewed. The application of tissue chip technique in screening of antibody,cell phenotype, expression of gene, genotyping, protein analysis, detecting of new gene were also explorcd.
作者 李军 刘镭 王一理
机构地区 陕西超英生物医学研究开发有限公司基础研究中心 西安交通大学基础医学院
出处 《肿瘤学杂志》 CAS 2002年第6期350-352,共3页 Journal of Chinese Oncology
基金 "十五"国家科技攻关西部开发重大项目资助(编号 :2001BA901A44)
关键词 组织芯片 蛋白表达 基因扩增 肿瘤 tissue microarray protein expression gene amplification neoplasms
分类号 R73 [医药卫生—肿瘤] Q503 [生物学—生物化学]
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参考文献15

  • 1Kononen J, Bubendorf L, Kallionieni A, et al. Tissue microarrays for high_throughput molecular profiling of tumor specimens[J]. Nature Med, 1998, 4(7): 844- 847.
  • 2Bowen C, Bubendorf L, James Voeller H, et al. Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression[J]. Cancer Res, 2000, 60(1):6111- 6115.
  • 3Miettinen HE, Jr Vinen TAH, Kellner U, et al. High topoisomerase Ⅱα expression associates with high proliferation rate and poor prognosis in pligodendrogliomas[J]. Neuropathol Appli Neurobiol, 2000, 26(6):504- 512 .
  • 4Schraml P, Struckmann K, Bednar R, et al. CDKN2A mutation analysis, protein expression ,and deletion mapping of chromosome 9p in conventional clear_cell renal carcinomas[J]. Am J Pathol, 2001, 158(2):593- 601.
  • 5Richter J, Wagner U, Kononen J, et al. High_throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer[J].Am Society Invest Pathol, 2000, 157(3): 787- 794.
  • 6Moch H, Lononen J, Kallioniemi OP, et al. Tissue microarray: what will they bring to molecular and anatomic pathology?[J]. Advan Anato Pathol, 2001, 8(1):14- 20.
  • 7Gillett CE, Springall RJ, Bames DM, et al. Multiple tissue core arrays in histopathology research: a validation study[J]. J Pathol, 2000, 192(2):549- 553.
  • 8Barlund M, Monni O, Kononen J, et al. Multiple genes at 17q23 undergo amplification and overexpression in breast cancer[J].Cancer Res 2000, 60(19):5340- 5344.
  • 9Bubendorf L, Kononen J, Koivisto P, et al. Survey of amplifications during prostate cancer progression by high- throughput fluorescence in situ hybridization on tissue microarrays[J]. Cancer Res, 1999, 59(2): 803- 806.
  • 10Schraml P, Kononen J, Bubendorf L, et al. Tissue microarrays for gene amplification surveys in many different tumor types[J]. Clin Cancer Res, 1999, 5(5):1966- 1975.

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肿瘤学杂志
2002年 第6期

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