黄芩汤有效成分配方对大鼠实验性溃疡性结肠炎的免疫调节作用

Experimental Research of Compound Elements of HuangQinTang Treating Experimental Ulcerative Colitis in Rat

采用三硝基苯磺酸法制备大鼠实验性溃疡性结肠炎模型 ,从细胞因子角度观察黄芩汤有效成分配方对实验性溃疡性结肠炎的治疗效果和作用机理。实验结果表明 ,模型组的IL - 1β、IL - 4含量与正常组比较均有显著性差异 (P <0 .0 1)。黄芩汤有效成分配方中剂量组与模型组比较能显著降低IL - 1含量 ,而提高IL - 4含量 (P <0 .0 1)。

A rat model of experimental ulcerative colitis was induced by administration of 2,4,6-trinitrobenzene sulfonic acid.The curative effect and mechanism that compound elements of HuangQinTang treat experimental ulcerative colitis were observed from cytokine.The result show that IL-1β?IL-4 had significant difference between model group and normal group(P<0.01).Meanwhile,the medium dosage group of compound elements of HuangQinTang can significantly increase the content of IL-1β and decrease the content of IL-4,which significantly differs from those of the model group(P<0.01) 〔