川乌加压炮制对乌头类生物碱含量的影响研究

The Effects on Content of Radix Aconiti Alkaloid through Pressurizing and Preparing Radix Aconiti

目的 :研究采用加压蒸汽对川乌药材进行炮制的方法。方法 :采用不同的蒸汽压力和蒸制时间处理药材 ,然后测定药材中中乌头碱、乌头碱、次乌头碱的含量变化。结果 :随着蒸汽压力的增大和蒸制时间的延长 ,川乌中三种主要的乌头类生物碱含量逐渐降低 ,在 0 .1Mpa蒸汽压力下蒸制 30分钟或 6 0分钟 ,乌头碱含量与按药典方法常压下蒸 8h的含量接近。结论 :本法可能作为川乌新的减毒增效的炮制方法 ,但加压炮制后的药材 ,药效有无变化 ,还需做进一步药理实验证实。

sObjective Research preparing method of radix aconiti by adopting pressurizing steam.Methods Adopt different steaming pressure and steaming time to treat with medicine materials,determine the content change of meaconitine,aconitine and hypaconitine.Results As steaming pressure increases and the steaming time extends,the three main alkaloid's contents decline.If being steamed 30 minutes or 60 minutes under 0.1 MPa steaming pressure,the aconitine's content approach to that being steamed 8 hours under usual pressure according the method of pharmacopeia.Conclusion This method can be taken as new preparing method of radix aconiti in reducing poison and adding effect,byt as pressurized and prepared medicine materials,it needs further pharmacology experiment verification in whether there is any change in medicine effects. 〔