深圳地区甲真菌病病原菌流行病学的多中心研究

Epidemilogical Survey of Pathogenic Fungi of Onychomycosis in Shenzhen

目的 了解深圳地区最近4年甲真菌病病原菌的种类和构成,发现流行病学特点。方法 以多中心研究方式选取深圳地区6家不同区域的主要医院,选取临床表现典型、真菌镜检阳性的1162例甲真菌病患者进行真菌分离培养。结果共培养出致病真菌553株。皮肤癣菌占68.53％,以红色毛癣菌为主占52.26％,其次是须癣毛癣菌占11.21％;酵母菌占25.68％,其中以白念珠菌最多占9.22％;霉菌占5.79％,主要是曲霉属和青霉属;混合感染占4.30％。结论深圳地区最近4年甲真菌病病原菌为皮肤癣菌、酵母菌和霉菌。红色毛癣菌和白念珠菌所占比例最高。

Objective To isolate the causative pathogens on onychomycosis in Shenzhen. Methods From the latest four years direct microscopic examination and culture were perfored on 1 162 samples from patients with clinical suspected onychomycosis in 6 hospitals which in different area of the city. Results 553 strains of pathogenic fungi were isolated. The most frequently isolated fungus was dermatophytes(68.53%),followed by yeasts(25. 68%)and saprophytic molds (5.79%). Conclusion Der-matophytes,yeasts and saprophytic molds are causative pathogens of onychomycosis in Shenzhen,T. rubrum and C. albican are the most common fungi.