摘要
[目的]观察尿多酸肽注射液单药治疗对晚期肿瘤患者的临床疗效及其毒副反应。[方法]尿多酸肽注射液300ml锁骨下静脉穿刺给药 ,每天1次 ,连续用药4周为1个疗程 ,2个疗程后评价疗效及其毒副反应 ,采用EORTCQLQ C30(V3.0)中文版评价生活质量。[结果]对25例晚期癌症患者进行Ⅱ期临床的观察 ,发现22例可评价疗效的患者中达PR者2例 (占9.09% ) ;QLQ C30生活质量15项领域中位有效改善率40% ;评价入组的25例患者的毒副反应发现除1例出现Ⅱ度骨髓抑制、1例出现Ⅲ度腹泻 (各占4 % )外 ,其主要的不良反应为头痛 (12% ) ,心、肝、肾等主要脏器未出现毒性作用。[结论]尿多酸肽可显著改善患者生活质量 ,且毒副反应轻微 ,呈现出一定的抗肿瘤作用。
To observe the clinical efficacy and adverse effects of Uroacitide in patients with advanced cancer.Twenty five cases with various kinds of advanced cancer were treated with Uroacitide once a day for 4 weeks as 1 course. Uroacitide was administered as a single agent in a dosage of 300ml through the catheter inserted into the deep vein.Response and quality of life (QOL)were evaluated after 2 courses by EORTC QLQ C30 (V3.0).Twenty five patients were enrolled in this study. There were 2 partial remission, 13 stable and 7 progression among 22 evaluable patients.The overall response rate of 22 evaluable patients was 9.09%.QOL was improved in 40%.25 patients were assessed for safety.No sever toxicity to heart, liver and kidney was found.There were 1 case with grade Ⅱ marrow supression and 1 case with grade Ⅲ diarrhoea.The major adverse effects wereⅠ～Ⅱgrade headache.[Conclusion]Uroacitide shows certain effectiveness against advanced cancer, and it can significantly improve the quality of life.
出处
《中国肿瘤》
CAS
2002年第11期673-675,共3页
China Cancer
关键词
肿瘤
治疗
尿多酸肽
Ⅱ期临床
生活质量
neoplasms
treatment
uroacitide
phase Ⅱ clinical trial
quality of life
