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γ-谷氨酰半胱氨酸合成酶基因及其调控 被引量：3

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摘要 γ-谷氨酰半胱氨酸合成酶 (γ GCS)基因由γ GCS HS基因和γ GCS LS基因组成 ,γ GCS HS基因的 5′ 端序列包括很多调控γ GCS HS基因表达的抗氧化剂反应元件。不同的细胞在不同的刺激物下 ,γ
作者 程磷令
机构地区 广州呼吸疾病研究所
出处 《国外医学（生理病理科学与临床分册）》 2002年第6期543-545,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 Γ-谷氨酰半胱氨酸合成酶 γ-谷氨酰半胱氨酸合成酶基因 基因表达调控
分类号 R341 [医药卫生—基础医学]
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参考文献18

  • 1Heping YANG,Jiaohong W,Huang ZZ,et al.Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit[J].Biochem J,2001,357(Pt 2):447-455.
  • 2Harju T,Kaarteenaho WR.Diminished Immunoreactivity of gamma-Glutamylcysteine Synthetase in the Airways of Smokers′ Lung[J].Am J Respir Crit Care Med,2002,166(5):754-759.
  • 3Gipp JJ,Mulcahy RT.Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene[J].Cytogenet Cell Genet,2000,88(1-2):130-132.
  • 4Rozet JM,Gerber S,Perrault I,et al.Structure and refinement of the physical mapping of the gamma-glutamylcysteine ligase regulatory subunit(GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma[J].Cytogenet Cell Genet,1998,82:91-94.
  • 5Walsh AC,Feulner JA,Reilly A.Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit:association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel[J].Toxicol Sci,2001,61 (2):218-223.
  • 6Rnest B,Terri G,Takahito K,et al.The Molecular Basis of a Case of gamma-Glutamylcysteine Synthetase Deficiency [J].Blood,1999,94(8):2890-2894.
  • 7Wild AC,Moinova HR.Timothy Mulcahy Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2[J].J Biol Chem,1999,274(47):33627-33636.
  • 8Hirota K,Matsui M,Iwata S,et al.AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1 [J].Proc Natl Acad Sci USA,1997,94:3633-3638.
  • 9Wilhelm D,Bender K,Knebel A,et al.The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction path-ways including Jun N-terminal protein kinases and p38 kinase by alkylating agents[J].Mol Cell Biol,1997,17:4792-4800.
  • 10Iwanga M,Mori K,Iida T,et al.Nuclear factor kB dependent induction of gamma-glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells[J].Free Radic Biol Med,1998,24:1256-1268.

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国外医学（生理病理科学与临床分册）
2002年 第6期

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