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雄激素受体基因(CAG)n微卫星多态性与疾病易感性 被引量：3

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摘要 雄激素受体 (AR)基因第一外显子中含有遗传多态性的 (CAG)n微卫星序列 ,此序列编码AR转录激活区中的多聚谷氨酰胺片段。近年来研究相继证实 ,AR中的多聚谷氨酰胺重复数与其转录活性负相关 ,并进而发现该微卫星多态性与前列腺癌、延髓脊髓性肌萎缩、雄激素不敏感综合征、乳腺癌、子宫内膜癌及卵巢癌等多种疾病的发生、发展密切相关。
作者 王钢
机构地区 第二军医大学病理生理教研室
出处 《国外医学（生理病理科学与临床分册）》 2002年第6期612-615,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 受体 雄激素 (CAG)n微卫星 基因多态性 易感性
分类号 R363.2 [医药卫生—病理学]
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参考文献25

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同被引文献38

  • 1杨淑云,李海霞,刘彩萍.原发性肝癌雄激素受体表达的临床病理研究[J].武警医学,2004,15(6):421-423. 被引量：1
  • 2沈富军,Phill Watts,张志和,张安居,Stephanie Sanderson,SteveJ.Kemp,岳碧松.Dynal磁珠富集大熊猫微卫星标记[J].Acta Genetica Sinica,2005,32(5):457-462. 被引量：14
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国外医学（生理病理科学与临床分册）
2002年 第6期

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