摘要
癫痫发作可诱导海马内脑源性神经营养因子 (BDNF)水平上调 ,进而激活海马门区及CA3区腔隙层的TrkB受体 ,通过促进兴奋性神经递质释放等效应加强海马通路尤其是苔状纤维的兴奋性突触传递 ,从而导致持续的高度兴奋状态 ;而阻断BDNF信号转导通路则可抑制癫痫发生。提示BDNF在癫痫发作过程中具有重要作用 。
出处
《国外医学（生理病理科学与临床分册）》
2002年第6期618-620,共3页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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