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胰岛素样生长因子-I与动脉粥样硬化 被引量：1

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摘要 动脉粥样硬化的发生发展与多种生长因子有关。本文就胰岛素样生长因子
作者 许端敏 李玉光
机构地区 汕头大学医学院第一附属医院心内科
出处 《汕头大学医学院学报》 2002年第4期238-239,共2页 Journal of Shantou University Medical College
关键词 胰岛素样生长因子-I 动脉粥样硬化 相关关系
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献10

  • 1Duan C,Bauchat JR, Hsieh T. Phesphatidylinsitol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migration[J].Circ Res, 2000,86(l): 15-23
  • 2Yano K, Bauchat JR, Liimatta MB et al. Down-regulation of protein kinase C inhibits insulin-like growth factor I-induced vascular smooth cell proliferation,migration, and gene expression[J]. Endocrinology, 1999, 140 (10):4622-4632
  • 3Glazebrook H, Hatch T, Brindle NP. Regulation of insulin-like growth factor-I expression in vascular endothelial cells by the inflammatory cytokine interleukin-I[J]. J Vasc Res,1998,35(3):143-149
  • 4Grant MB,Wargovich TJ,Ellis EA et al. Expression of IGF-I,IGF-I receptor and IGF binding proteins-1,-2,-3,-4 and -5 in human atherectomy specimens[J].Regul Pept, 1996,67:137-144
  • 5Wang J, Niu W, Nikiforov Y et al. Targeted overexpression of insulin-like growth factor I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice[J].J Clin Invest,1997,100:1425-1439
  • 6Pukac L,Huangpu J,Karnovsky MJ.Platelet-derived growth factor-BB,insulin-like growth factor-I,and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration[J].Exp Cell Res, 1998, 242 (2):548-560
  • 7Bai HZ, Pollman MJ, Inishi Y et al. Regulation of vascular smooth muscle cell apoptosis. Modulation of bad by a phosphatidylinsitol 3-kinase-dependent pathway[J].Cir Res,1999,85(3):229-237
  • 8Okura Y, Brink M, Zahid AA et al. Decreased expression of insulin-like growth factor-I and apoptosis of vascular smooth muscle cells in human athrosclerotic plaque[J]. J Mol Cell Cardiol,2001,33(10):1777-1789
  • 9Scheidegger KJ, James RW, Delafontine P. Differential effects of low density lipoproteins on insulin-like growth factor-I(IGF-I) and IGF-I receptor expression in vascular smooth muscle cell[J]. J Biol Chem,2000,275(35):26864-26869
  • 10Martinez GJ,Vials M, Vidal F et al. Mevalonate deprivation impairs IGF-I/insulin signaling in human vascular smooth muscle cells[J]. Atherosclerosis, 1997,135:213-223

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汕头大学医学院学报
2002年 第4期

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