胎儿主动脉早期病变的观察

Observation of Early Lesion in Embryo Aorta

目的 为了探索人胚胎期间的主动脉是否存在早期病变。方法 对 176例第 2～ 10月人胚胎主动脉定位取材、切片 ,用H E、Verhoeff等方法进行染色 ,并对 2 0 7例第 4～ 10月胎儿主动脉的整体标本用苏丹Ⅳ染色。结果 在 176例中发现 4例有早期病变 (脂纹斑I型 3例 ,II型 1例 ) ,最早出现于第 2 4周 ,检出率为 2 2 7%。 2 0 7例中有 1例第 2 6周胎儿在主动脉弓血管分支处附近显示了脂点 ,检出率为 0 48%。结论 人主动脉嗜苏丹性和早期病变并非始于婴儿期 ,而是始于胚胎发育的中、晚期 ,人胎儿主动脉内膜增厚既是正常发育和年龄性变化 。

Objective To explore if there exists early lesion in human embryo aorta. Method Human embryonic aorta of 176 cases aged from 2 to 10 months was took out and stained with methods of H.E and Verhoeff, and whole samples of human embryonic aorta of 207 cases aged from 4 to 10 mouth were stained by sudan Ⅳ .Results Early lesion was found in 4 of 176 cases (3 cases for fatty streak type 1, 1 case for type II), and the earlist one occured at the 24th week. Lipido-point was found around areas of driving blood flow in the arotic arch in one aged 26th week. Conclusion Early lesion does not begin in infant but at the middle or late period of embryonic development, the intimal thikening of human fetus aorta happened in no rmal and aging is the foundation of leading to atherosclerotic disease.