原发性高血压红细胞CR_1分子粘附活性和胸腺素的免疫调整作用

A Clinical Study on the Activity of Complex melt Receptor Type one (CR_1) on Erythrocyte in Patients with Essential Hypertension and Regulatory Action of Thymosin

目的探讨原发性高血压(EH)红细胞免疫粘附(red cell immune adherence,RCIA)病理机制和胸腺素的非特异性免疫调整作用。方法以酵母菌红细胞花环试验及PEG沉淀法测定99例EH者红细胞C_(3b)受体(RCR)活性、红细胞粘附免疫复合物(RICR)指标及循环免疫复合物(CIC)含量。并使用小牛胸腺素随机对其中48例EH进行免疫治疗,同时与51例常规治疗EH者及30例正常人在治疗前后对照上述指标。结果各期EH均出现RCR、RICR和CIC指标的显著异常(P<0.01或P<0.05)。免疫治疗组12周后各上述指标较对照组有显著改善(P<0.01或P<0.05),且对Ⅰ期EH的调整效果优于Ⅲ期组。结论RCIA功能障碍参与了EH动脉壁炎症损害的免疫病理过程。使用胸腺素对调整上述免疫异常具有一定作用。

Objective To investigate the pathogenesis related with the function of the red cell immune adherence (RCIA) in the patients with essential hypertension (EH) and the possibility of the nonspecific immunol regulation.Method Parameters of 99 EH patients were detected by the mixed rossett of erythrocyte and yeast , PEG precipatation respectively and were compaired between 48 of whom pre - and post - treatment with thymosin and the control group. Result The activity of RBC - CR1 in EH group was lower than that of normal group (P<0.01), but the ratio of RBC- IC rosette (RICR) and the content of CIC was increased significantly (P<0.01, P<0.05), The changes were observed in the group of thymosin treatment that the most of parameters of RCIA function were closed to the normal (P> 0.05) 12 weeks kter. Conclusions RCI-A function disturbance was involved in immunopathy prossess of EH and thymosin would improve the abilities of RBC to clear CIC and reduce the artery imflammatory injury in EH patients.