摘要
目的为了探讨尿蛋白-1(UP-)与糖尿病肾病的关系。方法用酶联免疫法测定了90例非胰岛素依赖型糖尿病(NIDDM)患者的UP-1,同时测定尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、β2-微球蛋白(β2-mG)。结果糖尿病患者UP-1均较正常对照组增高,UP-1与尿A1b、尿NAG和β2-mG呈正相关。结论在糖尿病早期阶段,肾小管会受到损害,UP-1可作为诊断早期糖尿病肾病的敏感指标。
Objective To study the relationship between urine protein 1 (UP- 1) and diabetic nephropathy.Methods The concentration of UP - 1 in the urine of NIDDM was measured by ELISA. The concentration of N - acetyl - beta - D - glucosamindase (NAG) and beta2 - mi-croglobulin (β2 - MG) in the urine were also measured.Results UP- 1 in all three groups was significantly higher than that in the control group.There is Positive correlation between UP- 1 and urine Alb. urine NAG and β2 - MG. Conclusion Renal tubular function has been damaged in the early diabetic nephropathy and UP- 1 is an indicator of the diagnosis of the early diabetic nephropathy.
出处
《医学研究通讯》
2003年第1期34-35,共2页
Bulletin of Medical Research
关键词
尿蛋白-1
糖尿病肾病
白蛋白
诊断
Urin protein 1 Diabetic nephnopathy Albumin Diagnosis
