生长抑素应用于急性轻型胰腺炎时血浆内毒素和TNFα水平变化

The efficacy of somatostatin in the treatment of mild acute pancreatitis and it's influence on plasma endotoxin and TNFα

目的 观察生长抑素 (施他宁 )对急性轻型胰腺炎的治疗效果及其对急性轻型胰腺炎患者血浆内毒素和TNFα水平的影响。方法 5 8例急性轻型胰腺炎患者随机分为A、B两组 ,A组采用施他宁治疗 (治疗组 ) ,B组给予一般常规治疗 (对照组 ) ,于第 1、3、5、7天抽血测定血闪内毒素和TNFα。结果 急性轻型胰腺炎患者入院第 1天的血浆内毒素和TNFα水平均明显高于健康人 ;治疗组患者血浆内毒素和TNFα水平下降速度明显快于对照组。结论 急性轻型胰腺炎患者早期均存在不同程度的内毒素血症及血浆TNFα水平升高 ,生长抑素治疗急性轻型胰腺炎疗效肯定 ,治疗组患者血浆内毒素和TNFα水平下降均明显快于对照组。

Objective To evaluate the efficacy of somatostatin in the treatment of mild acute pancreatitis and it's influence on plasma endotoxin and TNFα levels. Methods Fifty-eight patients with acute pancreatitis were studied. The patients were divided into two groups. Patients in group A were treated with somatostatin, patients in group B only accepted common treatment. On day 1, 3, 5, 7, plasma endotoxin and TNFα were examined. Results On day 1, plsama endotoxin and TNFα in group A and B were markedly increased compared with normal control group. During the therapeutic process, plasma endotoxin and TNFα in group A decreased more rapidly than in group B. Conclusions It was concluded that, in the early stage of acute pancreatitis, endotoximia and increased plasma TNFα commonly exists. Somatostatin was more effective.