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非基因毒性剂引起的癌症中基因外表型遗传性改变 被引量:1

Epigenetic Changes in Cancer Caused by Non-genotoxic Agents
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摘要 DNA甲基化的型式和染色质结构在肿瘤中有显著的变化,包括:基因组大范围的甲基化低下及局部的甲基化过度。关于染色质组成调控基因转录机制的最新研究突出了基因外机制在人类癌症的启动和进展中的重要性。这些基因外变化,特别是异常的启动子甲基化过度及相应基因的转录沉默,实际上影响着肿瘤进展的每一步。现复习由非基因毒引起的致癌性基因外表型的遗传性变化,并简介利用它们在癌症诊断、预后及治疗方面的研究进展。
出处 《中国肿瘤》 CAS 2003年第1期37-43,共7页 China Cancer
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参考文献13

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同被引文献5

  • 1Herman JG, Baylin SB. Promoter-region hypermethylation and gene silencing in human cancer[J]. Current Topics in Microbiology and Immunology, 2000,249 ; 35,.
  • 2Murphy SK, Jirtle RL. Non- genotoxic causes of Cancer[A]. IN:Alison M. The cancer Handbook[M]. London:Nature Publishing Group, 2002.317.
  • 3Li E, Jaenisch R.. DNA methylation and methyltransferases[A]. IN: Ehilich M. DNA Alterations in Cancer[M]. USA : Eaton Publishing, 2000. 351,.
  • 4Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer[J]. Nature Reviews Genetics, 2002,3:415.
  • 5薛开先.肿瘤表遗传学研究的进展[J].国外医学(遗传学分册),2003,26(1):1-5. 被引量:13

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