甲型流感病毒的抗原变异与流行

Antigen of Influenza A virus changing and popularizing

目的了解甲型流感病毒易发生变异的原因,寻求防止流行的办法。方法分析其基因组片段和编码的蛋白质与表型变异相比较来推断发生变异的原因。结果甲型流感病毒表面抗原发生变异由于糖蛋白变异引起,而这是由其基因组变异决定的,同时决定引起的是大或中、小流行。结论引起变异的原因有三个即点突变引起抗原漂移、基因重组引起抗原转变及动物流感病毒突变而感染人,其中基因重组是流感病毒发生抗原转变引起大流行的主要原因。

Objective:Realize the reason of easy changing of influenza A virus and look for a way of prevent its popularizing.Method:analyse its genome segment and its coding protein,then compare with its changing of surface type for infer the reason of changing.Result:The reason that surface antigen of influenza A virus changes is changing of sugar protein,this changing is brought by changing of its genome,and it determines big or middle or small popularization.Conclusion:The reasons of influenza A virus changing are point break beget antigen changing,genome recomposing beget antigen changing,break of influenza A virus of animal beget human infected,thereinto,genome recomposing is mostly reason of antigen changing beget big popularization.