摘要
目的:探讨氯沙坦对老年中重度原发性高血压患者内皮素和一氧化氮的影响。方法:氯沙坦组为年龄在60岁以上,经应用两种以上降压药物治疗后,收缩压仍≥160mmHg或舒张压≥100mmHg的患者,共48例。在原治疗的基础上加用氯沙坦50mg/d,共6周,观察加用氯沙坦治疗前后的血浆内皮素(ET)和一氧化氮(NO)水平的变化。并设健康对照组52名。结果:经氯沙坦治疗后ET明显下降,血浆NO水平比加药前升高。与对照组比较,ET加药前后均高于对照组;NO加药前比对照组低,加药后比对照组高,而ET/NO的比值,加药后比加药前降低,并达到正常对照组水平。结论:氯沙坦可能有助于改善患者的血管内皮功能和血管的收缩与舒张的平衡功能。
Objective: To investigate the effect of losartan on plasma endothelins (ET) and nitrogen mon oxide (NO) in elderly patients with moderate to severe essential hypertension. Methods: Forty-eight patients with essential hypertension who were≥60 years of age and had been treated with two or more antihy-pertensive drugs but whose systolic pressure were still≥160mmHg and or whose diastolic pressure were ≥ 100mmHg, entered into the present study. Losartan 50mg daily was added to their original treatment for 6 weeks. ET and NO were measured before and 6 weeks after treatment. Fifty-two healthy adults acted as controls. Results; In the treatment group,ET was significantly decreased and NO was significantly increased after 6 weeks' addition of losartan. As compared with controls, ET of treatment group was higher both before and after addition of losartan (P<0.001), NO was lower before addition of losartan (P =0.038) and higher after addition (P = 0.005). Before addition of losartan, the ratio of ET/NO in treatment group (2.2) was higher than that after addition(1.0,P<0.0001). After addition of losartan, the ratio of ET/NO in treatment group (1.0) did not differ significantly from that of controls (1.0 P = 0.819). Conclusions;Losartan may improve the endothelial function of elderly patients with moderate to severe essential hypertension.
