期刊文献+

肾性高血压大鼠血浆中降钙素基因相关肽与血管紧张素Ⅱ浓度及肾素活性的变化 被引量:7

The Changes of Plasma Concentration of Calcitonin Gene-related Peptide, Angiotensin Ⅱ and Renin Activity in Renal Vascular Hypertensive Rats
下载PDF
导出
摘要 降钙素基因相关肽与肾素—血管紧张素系统均参与血压的调节。在两肾一夹型肾性高血压大鼠模型 ,观察大鼠血浆中的降钙素基因相关肽、血管紧张素Ⅱ浓度及肾素活性的水平 ,以及用氯沙坦或培哚普利干预后这些活性肽在血浆中的变化 ,进一步分析这些血管活性肽在该模型的变化机制。研究显示 ,高血压组血浆中降钙素基因相关肽的浓度高于对照组 ,而血管紧张素Ⅱ与对照组相比无显著差异。用氯沙坦和培哚普利治疗 6周后 ,血浆中肾素活性和血管紧张素Ⅱ及降钙素基因相关肽水平均升高。本研究发现在肾性高血压中期 ,循环中肾素—血管紧张素系统对血压的影响已不是主要因素 ,降钙素基因相关肽的释放增加可能是血压升高的代偿作用。应用氯沙坦和培哚普利后可增加血浆中血管紧张素Ⅱ浓度和肾素活性 ,同时也增加降钙素基因相关肽的合成与释放 。 Aim To explore the levels of neurotransmitter of sensory nerves and constrictor peptides of renin angiotensin system in renal vascular hyertensive rats, and the changes of these peptides after treatment with losartan or peridopril. Methods The 2 kidney, 1 cliped rats hypertensive model were used, and the plasma concentration of active peptides were determined by radioimmunoassay method. Results The plasma concentration of calcitonin gene related peptide (CGRP) was slightly raised in hypertensive rats, compared with sham operation group, and treatment with losartan or peridopril had markedly elevated plasma concentration of CGRP as well as angiotensin Ⅱ and rennin activity. Conclusions In the metaphase of renal vascular hypertension, the elevation of CGRP may be a compensation action due to increasing of blood pressure. Chronic treatment with losartan or peridopril not only affects the releasing of CGRP, but also activates the circular renin angiotensin system in renal vascular hypertension.
出处 《中国动脉硬化杂志》 CAS CSCD 2002年第6期469-472,共4页 Chinese Journal of Arteriosclerosis
基金 国家 973项目 (G2 0 0 0 0 5 690 5 ) 国家自然科学基金(3 0 0 70 870 )资助
关键词 肾血管性高血压 降钙素基因相关肽 肾素 血管紧张素Ⅱ 大鼠 Hypertension, Renovascular Calcitonin Gene related Peptide Renin Angiotensin Ⅱ Rats
  • 相关文献

参考文献14

  • 1Kawasaki H,Takasaki K,Saito A,et,al. CGRP is a novel vasodilator neurotransmitter in mesenteric resistance vessels of spontaneously hypertensive rats. Nature,1988,335: 164-167
  • 2Yamada M,Ishikawa T,Fujimori A,et al. Enhanced depressor and hyperemic responses to calcitonin gene-related peptide in spontaneously hypertensive rats. Peptides,1998,19: 697-701
  • 3Kawasaki H. Effects of chronic administration of antihypertensive drugs on vasodilation mediated by calcitonin gene-related peptide-containing vasodilater nerves in mesenteric artery in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol,1992,19: 569-573
  • 4Kawasaki H,Takenaga M,Araki H,et al. Angiotensin inhibits neurotransmissin of calcitonin gene-related peptide-containing vasodilator nerves in mesenteric artery of spontaneously hypertensive rats. J Pharmacol Exp Ther,1998,284: 508-515
  • 5Supowit SC,Zhao H,Hallman DM,et al. Calcitonin gene-related peptide is a depressor of deoxycorticosterone-salt hypertension in the rat. Hypertension,1997,29: 945-950
  • 6Supowit SC,Zhao H,Hallman DM,et al. Calcitonin gene-related peptide is a depressor in subtotal nephrectomy hypertension. Hypertension,1998,31: 391-396
  • 7Palla R,Parrini M,Panichi V,et al. Acute effects of calcitonin gene-related peptide on renal haemodynamics and renin and angiotensin Ⅱ secretion in patients with renal disease. Int J Tissue React,1995,17 (1): 43-49
  • 8秦旭平,廖端芳,李元建.血管平滑肌细胞增殖及其调控[J].中国动脉硬化杂志,2001,9(5):450-454. 被引量:26
  • 9Wu W,Zhang Y,Ballew JR,et al. Development of hypertension induced by subpressor infusion of angiotensin Ⅱ: role of sensory nerves. Hypertension,2000,36 (4): 549-552
  • 10Kagiyama S,Varela A,Phillips MI,et al. Antisense inhibition of brain renin-angiotensin system decreased blood pressure in chronic 2-kidney,1-cliped hypertensive rats. Hypertension,2001,37 (Part 2): 371-375

二级参考文献13

  • 1Doi D,Arterioscler Thromb Vasc Biol,2001年,21卷,930页
  • 2Song R H,Arterioscler Thromb Vasc Biol,2000年,20卷,923页
  • 3Jin Z G,Circulation Research,2000年,87卷,9期,789页
  • 4Seki Y,Circulation Research,2000年,87卷,12页
  • 5Liao D F,JBiolChem,2000年,275卷,1期,189页
  • 6Wang X,J Mol Cell Cardiol,1999年,31卷,9期,1599页
  • 7Liao D F,JBiolChem,1997年,272卷,6146页
  • 8Li Y,Neuropeptide,1997年,31卷,5期,503页
  • 9Liao D F,Circulation Research,1996年,79卷,5期,1007页
  • 10Yu X J,Life Sci,1994年,14卷,746页

共引文献25

同被引文献52

  • 1刘子旺,杨瑞霞,韩景辉.首乌降压胶囊对肾性高血压大鼠血浆前列腺素、血栓素水平的影响[J].北京中医药大学学报,2006,29(8):534-536. 被引量:4
  • 2Jeffrey A, Richard G, Michael P, Zhang XL.p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression.J Biol Chem, 1999, 274 (45):32 333-341
  • 3Cobb MH, Goldsmith EJ.How MAP kinase are regulated.J Biol Chem, 1995, 270 (25):14 843-846
  • 4Song KS, Li S, Okamoto T, Quilliam LA, Lisanti MP.Copurification and direct interaction of Rsa with caveolin, an integral membrane protein of caveolae microdomains.Deterfent free purification of caveolae membranes.J Biol Chem, 1996, 271 (16):9 690-697
  • 5Kim JH, Han JM, Lee S, Kim Y, Lee TG, Lee SD, et al.Phoospholipase D1 in caveolae:regulation by protein kinase C alpha and caveolin-1.Biochemistry, 1999, 38 (12):3 763-769
  • 6Smart EJ, Ying YS, Donzell WC, Richard G.A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane.J Biol Chem, 1996, 271 (46):29 427-435
  • 7[4]Tang JA, Xu D, Yuan XQ, Meng ZH, Cheng FR, Chen MZ, et al. Calcitonin gene-related peptide in the patois and treatment of hypertension. Chin Med J, 1989, 102:897-901
  • 8[5]Supowit SC, Gururaj A, Ramana CV, Westlund KN, DiPette DJ. Enhanced neuronal expression of calcitonin gene-related peptide in mineralocoricoid-salt hypertension. Hypertension, 1995, 25:1 333-338
  • 9[6]Supowit SC, Zhao H, Hallman DM, DiPette DJ. Calcitonin gene-related peptides is a depressor of deoxycorticosterone-salt hypertension in the rat. Hypertension, 1997, 29:945-950
  • 10[7]Supowit SC, Zhao H, Hallman DM, DiPette DJ. Calcitonin gene-related peptides is a depressor in subtotal nephrectomy hypertension in the rat. Hypertension, 1998, 31:391-396

引证文献7

二级引证文献41

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部