肾性高血压大鼠血浆中降钙素基因相关肽与血管紧张素Ⅱ浓度及肾素活性的变化

The Changes of Plasma Concentration of Calcitonin Gene-related Peptide, Angiotensin Ⅱ and Renin Activity in Renal Vascular Hypertensive Rats

降钙素基因相关肽与肾素—血管紧张素系统均参与血压的调节。在两肾一夹型肾性高血压大鼠模型 ,观察大鼠血浆中的降钙素基因相关肽、血管紧张素Ⅱ浓度及肾素活性的水平 ,以及用氯沙坦或培哚普利干预后这些活性肽在血浆中的变化 ,进一步分析这些血管活性肽在该模型的变化机制。研究显示 ,高血压组血浆中降钙素基因相关肽的浓度高于对照组 ,而血管紧张素Ⅱ与对照组相比无显著差异。用氯沙坦和培哚普利治疗 6周后 ,血浆中肾素活性和血管紧张素Ⅱ及降钙素基因相关肽水平均升高。本研究发现在肾性高血压中期 ,循环中肾素—血管紧张素系统对血压的影响已不是主要因素 ,降钙素基因相关肽的释放增加可能是血压升高的代偿作用。应用氯沙坦和培哚普利后可增加血浆中血管紧张素Ⅱ浓度和肾素活性 ,同时也增加降钙素基因相关肽的合成与释放 。

Aim To explore the levels of neurotransmitter of sensory nerves and constrictor peptides of renin angiotensin system in renal vascular hyertensive rats, and the changes of these peptides after treatment with losartan or peridopril. Methods The 2 kidney, 1 cliped rats hypertensive model were used, and the plasma concentration of active peptides were determined by radioimmunoassay method. Results The plasma concentration of calcitonin gene related peptide (CGRP) was slightly raised in hypertensive rats, compared with sham operation group, and treatment with losartan or peridopril had markedly elevated plasma concentration of CGRP as well as angiotensin Ⅱ and rennin activity. Conclusions In the metaphase of renal vascular hypertension, the elevation of CGRP may be a compensation action due to increasing of blood pressure. Chronic treatment with losartan or peridopril not only affects the releasing of CGRP, but also activates the circular renin angiotensin system in renal vascular hypertension.