马斯平对医院常见致病菌活性实验研究及前景展望

The analysis on antimicrobial activity and foreground of maxpime against the clincial bacterial in hospital

目的 验证马期平 (头孢吡肟 )的抗菌谱 ,研究其在临床应用中的前景及意义。方法 用浓度梯度法E test法测定头孢吡肟对临床分离菌 4 0株的最低抑菌浓度 ,并与其他抗生素体外抗菌活性进行比较。结果 头孢吡肟对肠杆菌科抗菌活性强于第 3代头孢菌素 ,对铜绿假单胞菌的抗菌活性也较强 ,与亚胺掊南相当。对苯唑青霉素敏感的金黄色葡萄球菌较敏感 ,(MIC90 为 3mg/L)。 结论 头孢吡肟对革兰阴性杆菌的抗菌活性比第 3代头孢菌素强 ,且低诱导、低选择、高稳定 。

Objective To verify the antimicrobial spectrum of Cefepime and to study the foregroud and the clinical significance of Cefepine. Methods The minimal inhibitory cocentrations (MICs)of Cefepime against 40 clinical isolates were detemind by E test and the antimicrobial activity of Cefepime was compared with others. Results The activity of Cefepime was stronger than that of “the thirdgeneration” cephalosporins against enterobactercaceae,and sinilar th ceftazidime against Pseudomonas aeeruginoza.It was showed that Cefepime had been very acture agqainst Oxacillin susceptible staphylococci(MIC is 3 mirograms/L). Conclusions The antimicrobial activity of Cefepime is stronger than that of “the third generation” cephalosporins not only against gram negative bacilli but also against gram positivecocci.[