舒降之治疗老年人高胆固醇血症的疗效和安全性

The effection and safety of the simvastatin in treating senile hypercholesterolemia

目的 :探讨舒降之 (辛伐他汀 )治疗老年人高胆固醇血症的临床疗效和安全性。方法 :30例老年高胆固醇血症患者连续服小剂量舒降之 (5～ 10mg/d) 8周 ,治疗期间在第 4周和第 8周监测血脂、空腹血糖、肝功能、肾功能、肌酸激酶等。结果 :血脂改善总有效率总胆固醇 (TC)为 87% (2 6 / 30 ) ,甘油三酯 (TG)及高密度脂蛋白胆固醇 (HDL -C)均为 5 3% (16 / 30 ) ,低密度脂蛋白胆固醇 (LDL -C)为93% (2 8/ 30 )。治疗前后实验室检查结果差异无显著性 (p >0 .0 5 )。结论

Objective:To study the effection and safety of the simvastatin in treating senile hypercholesterolemia. Methods:Thirty senile patients with hypercholesterolemia were treated with small dose of simvastatin continously for eight weeks(5～10mg/d)The fasting blood lipid and blood sugar? the functions of the liver and the kidnep?creatine kinase were monitored. Results: The effective rate of the improvement in the blood lipid was as follows: TG was 87%, TG and HDL-C were both 53%, LDL-C was 93%. There was no significant difference in lab examination between before the treatment and the after. (p>0.05). Conclusion: It is effective and safe of small dose of simvastatin to treat senile hypercholesterolemia.