中脑导水管周围灰质内β-内啡肽对催产素增强电针镇痛的影响

EFFECT OF β-ENDORPHIN ON THE ENHANCEMENT OF ELECTROACUPUNCTURE ANALGESIA INDUCED BY OXYTOCIN IN PERIAQUEDUCTAI GRAY OF RATS

目的 探讨中脑导水管周围灰质 (PAG)内催产素 (OT)与内源性 β -内啡肽在电针镇痛中的相互关系。方法 以钾离子透入法引起大鼠甩尾反应的电流强度 (mA)为痛反应的指标 ,观察向PAG内注入OT和抗 β -内啡肽血清 ,对大鼠电针镇痛效应的影响。 结果 PAG内注入抗 β -内啡肽血清后 ,能明显降低电针镇痛的效应 ;但预先注入抗 β -内啡肽血清 ,并不能阻断OT增强电针镇痛的作用。 结论 PAG内OT在电针镇痛中的作用不依赖于PAG内的内源性 β

Objective To study the effect of oxytocin(O T) on electroacupuncture analgesia in periaqueductal gray(PAG) and its relation to endogenous β-endorphin.Methods The potassium iontophoresis induced tail-flick was used to measure the pain threshold. Results OT administration induced a enhancement of electroacupu ncture analgesia.Furthermore,pre-injection of AEPS in PAG not could weaken ana lgesia effect of OT.Conclusion These data suggest the enhancement of electroacupunc ture analgesia by OT is not dependent upon the β-endorphin in PAG.