776对原发不孕夫妇病因及细胞遗传学分析

Study on the causes and celluar genetics of 776 couples of primary infertility

目的 :探讨原发不孕的原因及诊断方法。方法 :1.夫妇双方一同就诊 ;2 .女方常规妇科检查、实验室及物理检查 ;3.分析男方精液 ,以WHO检验手册标准分析结果 ;4 .细胞遗传学染色体检查。结果 :776对原发不孕患者中 ,单纯女方异常 313对 ,占4 0 .34% ;单纯男方异常 178对 ,占 2 2 .94 % ;双方均异常 2 85对 ,占 36.73%。发现染色体异常 10 3例 ,异常检出率为 13.2 7%。结论 :1.重视男性不育和严格的精液检查在不孕症的诊断中至关重要 ;2 .在原发不孕中 ,染色体异常是重要原因之一 ,染色体异常导致的不孕多数是不可逆的 ,所以婚前的细胞遗传学检查染色体分析尤为重要 ,在了解自己的生育状况后 。

Objective:To study the causes and diagnostic methods of primary infertility by case analysis.Method:1.The couples went to gynecologist together;2.The female undertook routine gynecologic examination,laboratory and physical examination;3.The semen was analyzed according to WHO check directory;4.Cytogenetic chromosomal examination was undertaken in the couples.Results:The study was done in 776 couples of primary infertility.It was demonstrated 313 cases (40.34%) of simple female abnormality,178 cases (22.94%) of simple male abnormality,285 cases (13.27%) of male and female abnormality.103 patients (13.27%)were detected chromosomal abnormality in 776 couples.Conclusions:1.It is very important for the diagnosis of infertility to think highly of male abnormality and to take male semen examination.2.Chromosomal abnormality is one of the important causes of primary infertility.Infertility caused by chromosomal abnormality is almost irreversible,so cytogenetic chromosomal examination before marriage is necessary.