常压催化加氢制备间三氟甲基苯胺的方法研究

Manufacture of m-(Trifluoromethyl)aniline under Ambient Pressure by Catalytic Hydrogenation

在对文献报道的间三氟甲基苯胺的合成方法进行对比的基础上 ,以自制 Pd/C为催化剂 ,建立了常压催化加氢制备高纯度间三氟甲基苯胺的方法 ,确定了以底物比为 2 %,溶剂用量为 1 0 0m L无水乙醇 /0 .1 0 mol间三氟甲基硝基苯 ,氢化温度为 45°C,搅拌速度为 2 4 0 r/min的最佳氢化条件 ,氢化反应收率为 98.5 %,纯度为 99.3 %。

A method for manufacture of m-(trifluoromethyl)aniline under ambient pressure by catalytic hydrogenation is studied. The optimum conditions of catalytic hydrogenation are: 2% substrate ratio, 100 mL ethanol/0.10 mol m-(trifluoromethyl)nitrobenzene, 45°C and agitation rate 240 r/min. The purity of the product is 99.3%, and the yield is 98.5%.