摘要
A new binuclear copper?complex containing fluoroquinolone ligand, [Cu2（cfc）2（bpy）2（pip）]·6H2O, was synthesized and its crystal structure was solved. The formula of the complex is C25H26ClCuFN4O6, and the crystallography data are as follows, triclinic, space group ,a=6.874（2）?, b=10.761（3）?, c=17.976（5）?, α=80.071（6）°, β=85.253（6）°, γ=79.109（6）°, V=1284.5（6）?3, D=1.542g·cm-3, F（000）=614, and Z=2. R1=0.0776 and wR2=0.2235（I >2σ（I））. The copper atom is five coordinate with square based pyramidal geometry and involves two nitrogen atoms from bpy, two oxygen atoms from cfc and one nitrogen atom from pip anion. The stacking effect between cfc and bpy ligands from two neighboring molecules was observed. Both ligand and complex were assayed against gram positive and gram negative bacteria by doubling dilutions method, the complex shows the same minimal inhibitory concentration （MIC） as the corresponding ligand against S.Aureus and E.Coli bacteria. The inhibitory effect of the ligand and complex on leukemia HL 60 cell line and liver cancer BEL 7402 cell line have been measured by using MTT （Methyl Thiazol Tetrozolium） and SRB （Sulphurhodamin B） assay methods. The resultsindicated that the complex has strong inhibitory effect on HL 60 cell line and on BEL 7402 cell line. CCDC: 191087.
A new binuclear copper?complex containing fluoroquinolone ligand, [Cu_2(cfc)_2(bpy)_2(pip)]·6H_2O, was synthesized and its crystal structure was solved. The formula of the complex is C25H26ClCuFN4O6, and the crystallography data are as follows, triclinic, space group ,a=6.874(2)?, b=10.761(3)?, c=17.976(5)?, α=80.071(6)°, β=85.253(6)°, γ=79.109(6)°, V=1284.5(6)?3, D=1.542g·cm-3, F(000)=614, and Z=2. R1=0.0776 and wR2=0.2235(I >2σ(I)). The copper atom is five coordinate with square based pyramidal geometry and involves two nitrogen atoms from bpy, two oxygen atoms from cfc and one nitrogen atom from pip anion. The stacking effect between cfc and bpy ligands from two neighboring molecules was observed. Both ligand and complex were assayed against gram positive and gram negative bacteria by doubling dilutions method, the complex shows the same minimal inhibitory concentration (MIC) as the corresponding ligand against S.Aureus and E.Coli bacteria. The inhibitory effect of the ligand and complex on leukemia HL 60 cell line and liver cancer BEL 7402 cell line have been measured by using MTT (Methyl Thiazol Tetrozolium) and SRB (Sulphurhodamin B) assay methods. The resultsindicated that the complex has strong inhibitory effect on HL 60 cell line and on BEL 7402 cell line. CCDC: 191087.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2003年第2期179-182,共4页
Chinese Journal of Inorganic Chemistry
基金
国家自然科学基金资助项目(No.50073019)
