丹参注射液治疗不稳定型心绞痛的临床研究被引量：7

Clinical Effect of Danshen Injection on Unstable Angina Pectoris

下载PDF

导出

摘要目的 :研究不稳定型心绞痛 (UAP)患者血清中可溶性细胞间粘附分子 1(SICAM 1)和白介素 6 (IL 6 )的水平与正常人的差异 ,及其在丹参注射液治疗前后的变化 ,并且观察临床疗效。方法 :随机将 4 4例UAP患者分为单硝酸异山梨酯注射液治疗组 (欣康组 )和丹参注射液治疗组 (丹参组 ) ,观察治疗前后SICAM 1和IL 6水平的变化 ,并与 2 1例正常对照组对比分析。结果 :①UAP患者SICAM 1和IL 6水平较正常对照组明显升高 (P <0 .0 1) ;②欣康组、丹参组治疗后SICAM 1和IL 6水平较治疗前明显降低 (P <0 .0 1) ,且丹参组下降幅度较欣康组明显(P <0 .0 1) ;③丹参组的临床疗效与欣康组近似。结论 :①血清SICAM 1和IL 6水平可作为急性冠脉事件 (包括不稳定型心绞痛和急性心肌梗死 )发生的预测指标 ;②丹参注射液能显著降低UAP患者血清SICAM 1和IL 6水平 ,从而降低冠脉事件的再发生率。 Objective:To observe the difference of the level of soluble intercellular adhesion molecule 1(SICAM 1), interleukin 6 (IL 6) between healthy man and the patients with unstable angina pectoris(UAP),and the effect of Danshen injection on the level of SICAM 1, IL 6 in patients with UAP. Method: The patients with UAP were divided into two groups randomly. In additional to routine treatment,one group was treated with isosorbide 5 nitrate injection (Xinkang group)and the other group with Danshen injection(Danshen group).The levels of SICAM 1,IL 6 of two groups were observed.Result: ①The levels of SICAM 1 and IL 6 in the patients with UAP were higher than those of the healthy man(P<0.01). ②The levels of SICAM 1, IL 6 of Xinkang and Danshen groups after treatment were lower than those of procures. The decrement of the levels of SICAM 1 ,IL 6 in Danshen group was greater than that of Xinkang group. ③The curative effect of Danshen group was similar to that of Xinkang group. Conclusion: ①The levels of SICAM 1,IL 6 can be used as the prognostic indexes of acute coronary heart disease. ②Danshen injection can decrease the levels of SICAM 1, IL 6 efficiently so that it decreases reoccurrence rate of acute coronary syndrome.

作者邵敏徐岩

机构地区安徽医科大学第一附属医院心内科

出处《安徽中医学院学报》 CAS 2003年第1期13-16,共4页 Journal of Anhui Traditional Chinese Medical College

关键词丹参注射液不稳定型心绞痛可溶性细胞间粘附分子-1 白介素-6 单硝酸异山梨酯注射液鲁南欣康注射液 UAP Unstable angina pectoris Intercellular adhesion molecule 1 Interleukin 6 Isosorbide 5 nitrate injection Danshen injection Lu′nan Xinkang injection

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献2

1陈维洲.丹参的药理[J].药学学报,1984,19:876-880.
2车少敏.不稳定性冠脉粥样硬化斑块内炎症反应的病理生理学机制[J].心血管病学进展,2002,23(3):154-158. 被引量：32

二级参考文献29

1[1]Cullen P,von Eckardstein A,Assmann G. Diagnosis and maragenent of new cardiovascular risk factors[J]. Eur Heart J, 1998,19:13 - 19.
2[2]Ross R. Atherosclerosis - an inflammatory disease[J]. N Eng J Mec, 1999,340:115-126.
3[3]Biasucci LM,Golizzi C,et al. Role of inflammation in the pathogenesis on un stable coronary artery diseases[J]. Scand J Clin Lab Invest, 1999.50. (supp 230) : 12-22.
4[4]Depre C,Wijns W,Annie M,et al. Pathology of unstable plaque:correlauon with the clinic al severity of acute coronary syndromes[J]. J Am Coll Cardi ol,l997,30:694-702
5[5]Newby AC,Zaltsman AB. Fibrous cap formation or destruction -the critical importance of vascular smooth muscle cell proliferation, migration and ma trix formation[J]. Cardiovasc Res, 1999, 41 : 345-360.
6[6]van der Wal AC,Pidk JJ,de Boer OJ,et al. Recent onset activation of the plaque immune response iR coronary lesions underlying acute coronary syndromes[J]. Heart, 1998,80 : 14-18.
7[7]Onno J,Allard C,et al. Leucocyte recruitment in rupture prone regions of lipid-rich plaques:a prominent role for neovascularization[J]? Cardiovasc Res, 1 999, 41 : 443-449.
8[8]Collins T,Read MA,Neish AS,et al. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers[J]. FASEB J,1995,9:899-909.
9[9]Peng HB,Libby L,Liao JK. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B[J]. J Biol Chem, 1995,270:14214-14219,
10[10]Kaftan HA,Kaftan O,Kilic M. Makers of chronic infection and inf1amma tion: are they important in cases with chronic coronary hcart disease:[J].Jpn Heart J,1999,40:275-280.