生物芯片在临床医学中的应用

下载PDF

导出

摘要随着人类基因组计划的即将完成,蛋白质组计划已启动,面对人类基因组中的10万个基因,基因研究的重点开始由结构研究转向功能研究而进入后基因组时代,传统的一次只能研究少量基因的方法已显不足,生物芯片由此应运而生。生物芯片不仅在高通量基因测序、基因表达研究中发挥重要作用,

作者张丁丁杨明清

机构地区四川省人民医院检验科

出处《医学科技》 2002年第4期35-37,共3页

关键词生物芯片临床医学应用

参考文献10

1Chamber J,Angulo A,Amaratunga D,et al.DNA microarrays of the complex human cytomegalovirus genome:profiling kinetic class with drug sensitivity of viral gene expression[].Journal of Virology.1999
2Arenkov P,Kukhtin A,Gemmell A,et al.Protein microchips:use for immunoassay and enzymatic reactions[].Anna]Biochem.2000
3Toesch AJ,Varadi A,Rasko I,et al.Mycobaterium species identification and rifampin resistance testing with high-density DNA probe arrays[].Journal of Clinical Microbiology.1999
4Lopez Crapez E,Livache T,Marchand J,et al.K- ras mutation detection by hybridization to a polypyrrole DNA chip[].Clinical Chemistry.2001
5Wen WH,Bernstein L,Lescallett J,et al.Comparison of TP53 mutations identified by oligonucleotide microarray and conventional DNA sequence analysis[].Cancer Research.2000
6Velev OD.Assembly of protein structures on liposomes by non-specific and specific interactions[].Advances in Biophysics.1997
7MacBeath G,Schreiber SL.Printing proteins as microarrays for highthroughput function determination[].Science.2000
8Taton T A,Mirkin C A,Letsinger R L.Scanometric DNA Array Detection with Nanoparticle Probes[].Science.2000
9Westin L,Xu X,Miller C,et al.Anchored multiplex amplification on a microelectronic chip array[].Nature Biotechnology.2000
10Hacia J G,Makalowski W,Edgemon K,et al.Evolutionary sequence comparisons using high-density oligonucleotide arrays[].Nature Genetics.1998

医学科技

2002年第4期

内容加载中请稍等...