1Murray CJ, Lopez AD. Global mortality, disability, and the contri2bution of risk factors: Global burden of disease study[ J ]. Lancet,1997, 349: 1436 - 1442.
2Lecrubier Y. The burden of depression and anxiety in generalmedieine[ J ] . J Clin Psychiatry, 2001, 62 (8) : 4-9.
3Blier P , Gobbi G, Haddjeri N , et al . Impact of sub- stance Preceptor antagonism on the serotonin and norepi- nephrinesystems : relevance to the antidepressant/ anxio- lytic response[J] . J Psychiatry Neurosci ,2004 ,29 (3) : 208 - 218.
