缺血再灌注脊髓组织中白细胞介素-8表达的实验研究

The Experimental Study of Interleukin-8 Expression During the Spinal Cord Ischemia/Reperfusion

目的 观察兔缺血再灌注脊髓组织中白细胞介素 - 8(IL - 8)的表达 ,探讨其对脊髓缺血再灌注损伤的影响。方法 采用免疫组织化学和组织病理学方法 ,检测并观察兔缺血再灌注不同阶段脊髓组织中IL - 8的表达情况及病理改变。结果 随着缺血及再灌注进程、脊髓组织病理变化的加重 ,组织中IL - 8阳性表达强度逐渐增加。结论 缺血再灌注脊髓组织中IL -

Objective To observe and understand the expression and effect of interleukin-8(IL-8) in spinal cord during the ischemia / reperfusion(I/R). Methods The expression of IL-8 and histopathologic changes in spinal cord I/R were evaluated by means of immunohistochemical and histopathology. Results The positive expression of IL-8 progressively increased following reperfusion and histopathologic exacerbation. Conclusion The increase of IL-8 production may be one of the mechanisms in the spinal cord I/R injury.