氯烯雌酚醚对围绝经期及绝经后妇女骨丢失的影响

The Effect of Chlorotrianisene on Bone Loss in Perimenopausal and Postmenopausal Women

目的 评价氯烯雌酚醚对围绝经期及绝经后妇女骨丢失的影响。方法 5 9例围绝经期及绝经后患者 ,随机分成氯烯雌酚醚组 ( 3 8例 )和对照组 ( 2 1例 )两组。治疗前及治疗后 6个月各测 1次血、尿骨代谢生化指标。在治疗前及治疗后 2年时用DEXA测定股骨颈及腰椎的BMD。结果 治疗前两组间各指标差异无显著性 (P >0 .0 5 )。治疗后氯烯雌酚醚组的血清BGP及尿HOP/Cr均较对照组为低 ,而BMD较对照组为高 ,差异有显著性 (P <0 .0 5 )。氯烯雌酚醚组治疗后血清BGP、尿HOP/Cr及BMD均较治疗前有所下降 ,除BMD外 ,均有统计学差异 (P <0 .0 1) ;对照组治疗后血清BGP、尿HOP/Cr水平较治疗前有所上升 ,BMD较治疗前有所下降 ,均有统计学差异 (P <0 .0 1,P <0 .0 5 )。结论 氯烯雌酚醚能抑制围绝经期及绝经后妇女的高骨转换状态 。

Objective To investigate the influence of chlorotrianisene in perimenopausal and postmenopausal bone loss.Methods Fifty-nine perimenopausal and postmenopausal women were randomly divided into two groups ,given chlorotrianisene or calcium. Serum or urine bone metabolic indexes were measured at the beginning and 6 months after treatment. BMD at lumbar and femur neck were determined by DEXA at the beginning and 2 years after treatment.Results No significances of the observed indexes were seen between the two groups before freatment.After treatment, chlorotrianisene group compared to Control group, serum BGP and urine HOP/Cr were lower, BMD higher, and the differences were significant (P<0.05). Post-treatment compared to pre-treatment, serum BGP and urine HOP/Cr and BMD were lower in chlorotrianisene group-except BMD, the diffe rences were significant also. In Control group, post-treatment compared to pre-treatment,serum BGP and urine HOP/Cr were higher ,BMD lower ,and the compares made significance.Conclusion Chlorotrianisene could inhibit high bone turn-over in perimenopausal and postmenopausal women, prevent and treat bone loss.