不同年龄增生性瘢痕转化生长因子β_1表达的检测及其意义

The effects of TGF-β_1 expression on age-factor of hypertrophic scar formation

目的通过观察不同年龄增生性瘢痕与正常皮肤组织中转化生长因子β1(TGF-β1)的表达,初步探讨TGF-β1的表达与增生性瘢痕形成的年龄因素的关系。方法以增生性瘢痕为研究对象,正常皮肤组织为对照,采用SABC免疫组化方法观察1～19岁、20～50岁增生性瘢痕与各年龄组正常皮肤的细胞因子TGF-β1的表达。结果增生性瘢痕组织的TGF-β1含量显著大于正常皮肤。1～19岁增生性瘢痕组TGF-β1表达较20～50岁增生性瘢痕组的增高差异有具显著性意义(P<0.01)。胎儿组皮肤TGF-β1表达低于正常皮肤(P<0.01)。结论TGF-β1表达增高是增生性瘢痕形成的原因之一。

Objective To investigate the relation of the TG F-β 1 expression and the hypertrophic sca r formation of different age peri-ods.Method The expression of Cytokine TGF-β 1 was measured with Immunohistochemi stry in hypertrophic scar which is di vided by 1～19years old group and 20～50years old group and normal skin.Results The expression of TGF-β 1 protein in hypertrophic scar was en-hanced.The expression of TGF-β 1 in hypertrophic scar group of 1～19ye ar old significantly increased more than the group of 20～50year old(P<0.01).Significant decrease in expressio n of fetus group was observed than oth er normal skin group(P<0.01).Conclusion In-creasing expression of TGF-β 1 is a cause that forms hypertrophic sc ar.