P300对闭合性颅脑外伤患者脑认知功能康复的评估价值

Evaluation value of P300 to rehabilitation of cognition function in patients with closed craniocerebral trauma

目的研究P300对闭合性颅脑外伤患者脑认知功能康复的评估价值。方法应用Medicid-03E脑诱发电位仪测定91例闭合性颅脑外伤患者的视觉(图像)刺激诱发的异常P300波潜伏期(PL)和波幅(AMP),并对其进行比较分析,同时比较不同伤情、伤后不同时间患者的P300波。结果伤后不同时间P300波的PL和AMP差异有非常显著性意义(P<0.001);伤后不同伤情的患者不同时间的P300PL和AMP差异均有显著性意义,尤以原发性昏迷者为突出。结论P300波的变化可作为判断闭合性颅脑外伤患者脑认知功能康复的一项客观指标。

Objective To study the evaluation value of P300to rehabilitation of cognition function in patients with closed craniocerebral trauma.Method With medicid-03E brain evoked poten tial instrument,the latency and the amplitued of abnormal P300evoked by visual(image)stimulation were compared and analy zed between 91patients with closed c raniocerebral trauma and were compared with the P300during different condition of injur y and different time after injury.Results There was very remarkeble difference in latency and amplitude of P300between different time after in jury(P<0.001)and during different condition afte r injury,especially in patients wit h idiopathic coma (P<0.001).Conclusion The change of P300might be taken as an objective index of rehabilitation o f cognition function of brain in pati ents with closed craniocerebral trauma.