基因识别计算方法的回顾与展望

A Review and Prospect in Computational Methods for the Identification of Genes

经过 2 0多年的努力 ,匿名基因组序列基因识别领域取得了引人入胜的成就。基因识别程序已经从最初识别细菌基因组编码蛋白质区域向预测具有多外显子脊椎动物基因的详细结构发起挑战。在基因识别的过程中 ,计算方法扮演着重要的角色。不过 ,对预测的结果进行实验验证仍然是必不可少的过程。需要进一步发展和完善具有对长度以百万碱基对为单位的匿名基因组序列进行自动识别的算法和程序。

Development new methods to identify genes in anonymous genomic sequences have been going on for more than 20 years. In the time, the field has evolved from the designing of programs to identify protein coding regions in bacterial genomes, to the challenge of predicting the detailed organization of multi-exon vertebrate genes. Computational methods are indeed very useful.However,experimental validation is necessary for predicting result. The fully automated annotation of megabase-long anonymous genomic sequences is the next big challenge in bioinformatics.