绿茶儿茶素对诱发乳腺癌大鼠免疫功能的影响

Effect of green tea catechin on the immunological function of rats with Induced-Mammary tumor

目的 :研究癌前病变过程中绿茶儿茶素对免疫功能的调节作用。方法 :采用二甲基苯蒽诱发的大鼠乳腺癌癌前病变模型。将大鼠随机分成4组 ,即对照组、二甲基苯蒽 (DMBA)组、绿茶儿茶素 (GTC)组及DMBA +GTC组 ,测定大鼠胸腺重量、巨噬细胞吞噬功能及T淋巴细胞增殖能力。结果 :绿茶儿茶素可延缓大鼠胸腺器官的衰退 ,DMBA +GTC组巨噬细胞功能和T淋巴细胞增殖能力均高于其它组(P<0.05) ,在4组中对照组T淋巴细胞增殖能力最低(P<0.05)。结论 :绿茶儿茶素可通过免疫调节机制在预防肿瘤发生上起一定作用。

Objective: To study the effect of GTC on immunological function in process of tumor occurrence.Methods:The rats were random divided into four groups (control, DMBA, GTC and DMBA+GTC groups).The thymus weight, macrophage function and T lymphocyte proliferation were detected in process of mammary pretumor induced by DMBA.Results: GTC could delay diminution of thymus gland. The activities of macrophage and T-cell of the DMBA+GTC group all were significantly higher than those of other three groups. In control group T lymphocyte proliferation was the lowest of four groups.Conclusion: GTC could prevented from tumor by regulating immunological function.