摘要
猪6头,鸡10只,单剂量0 4065mg·kg-1(比活度24 6μci mg-1)静注给药,一个月后,单剂量31 15mg·kg-1(比活度5 187μci·mg-1)口服给药,进行代谢动力学研究。依据本实验建立的方法,以液体闪烁谱仪计数法进行含量测定。喹烯酮以原药的形式代谢排泄,静注给药符合二室开放模型:猪,T1/2α=0 1899h,T1/2β=4 5528h,Kel=0 8654h-1,AUC=0 00925mg·h-1·L-1;鸡,T1/2α=0 1637h,T1/2β=3 8189h,Kel=1 6834h-1,AUC=0 005046mg·h-1·L-1。口服给药符合一级吸收一室开放模型:猪,T1/2Ka=0 4678h,T1/2β=3 7445h,Tp=1 3367h,Cmax=0 000713μg·ml-1,AUC=0 00303mg·L-1·h-1;鸡,T1/2Ka=0 5142h,T1/2β=4 6637h,Tp=1 8459h,Cmax=0 000897μg·m-1,AUC=0 00773mg·L-1·h-1,说明喹烯酮口服给药后,其吸收较快,消除相对也较快,生物利用度低。
Normal pigs and chickens were given quinocetone iv 04065 mg·kg-1(rate radioactive degree 246μci·mg-1)and po 3115 mg·kg-1(rate radioactive degree 5187 μci·mg-1)after a month.The concentrations of quinocetone were determined by an liquid flamed chromatographic machine methed developed in our laboratory.The method is simple,sensitive and available for pharmacokinetics studies.The excretion type of quinocetone was also the beginning type.Plasma drug concentrationtime course of quinocetone after iv administration of quinocetone was found to be fitted to two compartment open model and its pharmacokinetic parameters were as follows:pigs,T1/2α=01899h,T1/2β=45528h,Kel=08654h-1,AUC=000925 mg·h-1·L-1;chickens,T1/2a=01637 h,T1/2β=38189 h,Kel=16834 h-1,AUC=0005046 mg·h-1·L-1.Plasma drug concentrationtime course of quinocetone after po administration of quinocetone was found to be fitted to one compartment open model with first order absorption and its pharmacokinetic parameters were as follows:pigs,T1/2Ka=04678 h,T1/2K=37445 h,Tp=13367 h,Cmax=0.000713 μg·ml-1,AUC=000303 mg·L-1·h-1;chickens,T1/2Ka=05142 h,T1/2K=46637 h,Tp=18459 h,Cmax=0000897 μg·ml-1,AUC=000773 mg·L-1·h-1.The experiment showed that the absorption and excretion of quinocetone were fast and its availability was low after po administration.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2003年第1期94-97,共4页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
关键词
喹烯酮
猪
鸡
药代动力学
Quinocetone
Quinocetone labeled by ^(14)C
Pharmacokinetics
LFCM