弥漫性大B细胞淋巴瘤临床病理分析

A Clinicopathological Study of Diffuse Large B-cell Lymphoma

目的 :研究弥漫性大B细胞淋巴瘤 (DLBCL)临床病理特点。方法 :在光镜下对DLBCL分型 ,用免疫组化ABC法研究DL BCL的免疫表型特点 ,使用的抗体有CD2 0、CD79、CD10、CD45RO、CD30、CD6 8、CD43、CD5、bcl 2、EMA、CK、S 10 0等。结果 :根据不同的形态学特点可将DLBCL分为以下几种亚型 :中心母细胞性 13例、免疫母细胞性 3例、浆母细胞性 1例、B间变性大细胞淋巴瘤 2例 ,大多叶核淋巴瘤 1例和富于组织细胞和 (或 )T细胞的大B细胞淋巴瘤 3例。一般均表达B细胞相关抗原 ,有 4例表达T相关标记CD43。结论 :DLBCL是具有异质性的一组淋巴瘤 ,具有较宽的细胞谱系 ,掌握其形态学特点对于正确诊断具有重要意义。

Objective:To study the clinicopathological characteristics of Diffuse large B-cell lymphoma(DLBCL).Methods:Based on the morphology,DLBCL could be divided into different subtypes. Imuno-histochemistry was performed in paradin sections,using the antibodies of CD20,CD79,CD3,CD68,CD43,CD10,CD5,CD30,CK, S-100, and EMA.Results:Group DLBCL can be subdivided as follows:13 cases of centroblast, 3 cases of immunoblast, 1 case of plasmoblast, 2 cases of B anaplastic lymphma and 3 cases of histiocyte or large B cell lymphoma with T cells and 1 case of multilobulated lymphoma. Most cases express the Pan-B markers, few cases can express the T cell marker CD43.Conclusion:DLBCL is a group of heterogenious lymphoma with a wide cellular spectrum. The knowledge of the morphology is important in correct diagnosis.