乳腺癌中组织蛋白酶-D表达水平与预后的关系

THE RELATION BETWEEN EXPRESSION LEVEL OF CATH-D AND PROGNOSIS IN BREAST CANCER

目的 :研究组织蛋白酶 -D(Cath-D)表达与乳腺癌预后的关系。方法 :采用免疫组化 S-P法 ,检测90例乳腺癌中 Cath-D表达并做术后随访调查。结果 :1 .Cath-D表达阴性组生存率最高 ,其 1、3、5、1 0 a生存率分别为 97.6%、91 .3 %、86.9%、78.5 % ;弱阳性组次之 ,为 93 .5 %、75 .1 %、71 .2 %、62 .5 % ;强阳性组生存率最低 ,为 90 .0 %、43 .5 %、3 5 .8%、3 2 .5 % ,经统计学处理 ,差异有显著性 (P <0 .0 1 )。 2 .采用 COX回归模型 ,对年龄、肿瘤大小、组织学类型、腋淋巴结转移、Cath-D表达 5个因素进行多因素回归分析 ,结果表明 ,肿瘤大小、腋淋巴结转移、Cath-D表达是影响预后的独立因素。结论 :Cath-D有可能作为预测乳腺癌预后的有效生物学指标 。

Objective: To study the expression level of Cath\|D in the breast cancer and its correlation with prognosis. Methods: In 90 breast cancer patients, Cath\|D was examined immunohistochemically and patients prognosis was evaluated by retrospective analysis combined with follow-up data. Results: 1. 1,3,5,10 year survival rate of the group with negative Cath-D expression was 97.6%, 91.3%, 86 9%, 78.5% and 93.5%, 75.1%, 71.2%, 62.5%, respectively, as to the group with weak positive Cath-D expression; in contrast, the group with strong positive was 90.0%, 43.5%, 35.8%, 32.5%, respectively. Significant difference was seen among three groups. 2. Multivariate survival analysis by COX regression model showed that Cath\|D expression level was a risky prognostic factor for breast cancer. Conclusion: Cath\|D may be the useful marker in predicting the prognosis of breast cancer, especially in the case of breast cancer without axillary lymphnode metastasis.\;