摘要
目的 探讨环孢素A (CsA)慢性肾毒性的发生机理。方法 采用放射免疫分析的方法 ,观察进低盐饮食的大鼠在灌服CsA 30mg·kg- 1 ·d- 1 2 8d后血浆肾素活性 (PRA)、血管紧张素Ⅱ(AngⅡ )、醛固酮水平的变化 ,以及复方丹参注射液、贝那普利对上述改变的防护作用。结果 CsA可引起大鼠血浆PRA、AngⅡ水平明显升高 ;丹参对这些改变影响不明显 ,而贝那普利对大鼠PRA、AngⅡ水平的升高有明显的抑制作用。血浆醛固酮水平 ,各组比较 ,只有给予贝那普利者明显下降 ,其余各组之间血浆醛固酮水平的差异无显著性 (P >0 .0 5)。结论 CsA的慢性肾毒性损伤可能与肾素 血管紧张素系统 (RAS)的激活 ,尤其是与AngⅡ的增加有关 ;
Objective To explore the mechanisms of cyclosporin induced chronic nephrotoxicity. Methods Radioimmunoassay was used to study the changes of plasma renin activity (PRA), plasma angiotensin Ⅱ (AngⅡ), and Aldosterone after rats were given low salt diet and 30 mg·kg -1 ·d -1 of CsA for 28 days. The protective effects of Radix Salviae Miltiorrhizae or benazepril on these changes were also studied. Results In CsA treated rats, PRA and AngⅡlevels were significantly elevated as compared with control groups. The elevation was not influenced by injection of Radix Salviae Miltiorrhizae, but could be blocked markedly by benazepril. There was significant difference in Aldosterone levels among the groups except benazepril treated group showing a decreased Aldosterone level.Conclusion Chronic cyclosporone nephropathy may be related to activation of renin angiotensin system, especially to the elevation of AngⅡlevels. The different effects of Radix Salviae Miltiorrhizae or benazepril on RAS suggest the different preventive mechanisms of the two drugs to chronic cyclosporine nephropathy. The plasma Aldosterone levels were not elevated in CsA treated rats, suggesting that CsA may induce relative adrenal resistance to AngⅡ.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2003年第1期15-17,共3页
Chinese Journal of Organ Transplantation
基金
河南省自然科学基金资助项目(01110250 0 0 )
