中药抗炎清肾方对免疫复合物性肾炎大鼠的保护作用

Renoprotective effects of Chinese herb in rats with immue complex glomerulonephritis

目的 采用阳离子化牛血清白蛋白 (C -BSA)诱发的免疫复合物性肾炎大鼠模型 ,观察中药抗炎清肾方对该模型大鼠的保护作用。方法 将造模大鼠随机分为模型组和中药组 ,分别给予抗炎清肾方汤剂及生理盐水灌胃 ,并与正常大鼠作空白对照。结果 中药组尿蛋白的排泄量较模型组显著减少 (P <0 .0 5 ) ,血清白蛋白水平增高 ,血脂水平降低 (P <0 0 5 )。中药组大鼠肾小球免疫复合物的沉积比模型组明显减少 ,基底膜增厚减轻 ,免疫组化显示基底膜IgG、Ⅳ型胶原的沉积均较模型组减轻。

Objective The study was designed to observe the renoprotective effect of Chinese herb in rat glomerulonephritis model of immune complex induced by cationic bovine serum albumin. Methods Rats with immue complex glomerulonephritis were randomly assigned to model group or Chinese herb group. Healthy rats were used as normal control.Results As compared to model group, Chinese herb-treated rats showed less urinary protein excretion( P <0.05), higher serum albumin( P <0.05) and less renal pathological injury. Immunohistochemistry staining indicated that there were less IgG and collagen IV deposition in Chinese herb-treated group( P <0.05).Conclusion Chinese herb has renoprotective effect in rats with immue complex glomerulonephritis.