类风湿关节炎患者滑膜树突状细胞的研究

Dendritic cells on synovial membranes in patients with rheumatoid arthritis

目的 探讨滑膜树突状细胞在类风湿关节炎 (RA)中的作用。方法 采用免疫组织化学方法观察 2 5例RA滑膜中HLA DR抗原阳性表达细胞、S 10 0阳性CD1a阳性的树突状细胞(DC)的多少和分布情况。结果 2 3例RA滑膜细胞HLA DR表达阳性 ,19例S 10 0表达阳性 ,16例CD1a表达阳性 ,其阳性例数的百分率均高于对照组。RA滑膜中HLA DR、S 10 0和CD1a标记阳性细胞数均明显高于对照组 ,其差异有非常显著意义 (P <0 0 1)。结论 RA滑膜中DC和被激活的DC及HLA DR阳性细胞的存在和增多可能在RA病变局部递呈自身抗原的过程中起重要的作用 。

Objective To explore the effects of dendritic cells (DC) on synovial membranes in patients with rheumatoid arthritis (RA).Methods The number and the distribution of HLA DR +,S 100 + and CD1a + cells on synovial membranes in 25 patients with rheumatoid arthritis were investigated with immunohistochemical staining.Results The case percentages of HLA DR,S 100 and CD1a positive expression on synovial membranes in patients with RA were higher those that in the control.The positive numbers of patients with RA were 23,19 and 16 respectively.The number of HLA DR +,S 100 + and CD1a + cells on synovial membranes were very significantly higher in patients with RA than in the control ( P <0 01).Conclusion The existence and the incremental numbers of DC,activated DC and HLA DR + cells may play an important role in the procedure of submitting autoantigens is the local lesion of RA.It is an important and beginning factor for the abnormal autoimmunity of RA.