激活素A作为肝硬化血清学指标的潜在意义

Serum Activin A Level as a New Maker for the Evaluation of Liver Cirrhosis

目的探讨血清激活素A作为肝硬化临床参考指标的可能性。 方法采用酶联免疫吸附试验测定45例肝硬化患者和23例正常对照者血清激活素A、Ⅲ型前胶原肽及Ⅳ型胶原。 结果肝硬化患者血清激活素A较正常对照者明显升高(P<0.05),分别与血清Ⅲ型前胶原肽、Ⅳ型胶原和丙氨酸氨基转移酶正相关(P<0.05)。 结论血清激活素A有可能成为新的肝硬化临床参考指标。

Objective To asress evaluate the possibility of serum activin A as a clinical marker for liver cirrhosis. Methods Using ELISA method to measure the serum levels of activin A, procollagen Ⅲ peptide, and collagen Ⅳ in 45 liver cirrhosis patients and 23 normal subjects. Results Compared with those of normal subjects, the serum activin A levels were significantly increased in liver cirrhosis patients (P <0. 05). The degree of elevation of serum acticin A was positively correlated with procollagen Ⅲ peptide, collagenⅣ and alanine aminotransferase(P < 0. 05). Conclusion Serum activin A may act as a clinical marker of liver cirrhosis in the future.