葛根素对豚鼠卡那霉素耳中毒听觉诱发电位的影响

The Effects of Puerarin on Brainstem Auditory Evoked Potentials of Ototoxicity with Kanamycin in Guinea-pigs

观察葛根素在豚鼠卡那霉素耳中毒中的作用。将豚鼠 30只随机分两组 :对照组 15只 ,肌注卡那霉素 40 0mg/kg/d ,共 12天 ;葛根素组 15只 ,除肌注卡那霉素 40 0mg/kg/d外 ,腹腔注射葛根素 10mg/kg/d ,共 12天。以听觉诱发电位为指标进行组间比较 ,听觉诱发电位阈值对照组明显高于葛根素组 (P <0 0 5 ) ;对照组诱发电位各波幅值则明显低于葛根素组 (P <0 0 1)。葛根素能减轻卡那霉素耳毒性 ,对卡那霉素耳中毒具有一定的保护作用 。

The protective role of Puerarin in the ototoxicity of guinea-pig induced by kanamycin was observed. 30 guinea-pigs were divided randomly into two groups. 15 guinea-pigs of control group were given kanamycin 400mg/kg/d by muscular injection for 12 days. Another 15 guinea-pigs,except giving kanamycin injection,were injected Puerarin 10mg/kg/d by abdominal for 12 days. The brainstem auditory evoked potentials (BAEPs) in two groups were compared by non-paired test. The threshold of BAEPs was increased by kanamycin in control group and the amplitude of BAEPs wave was lower than that of Puerarin group. Puerarin can relieve the ototoxicity of kanamycin in guinea-pigs and plays a protective role in hearing injury induced by kanamycin. Puerarin is helpful for the prevention of ototoxicity induced by ototoxic antiseptic drug.