美托洛尔治疗慢性心力衰竭的临床疗效

Clinical effect of metoprolol in treatment of chronic heart failure

目的 :研究美托洛尔治疗慢性心力衰竭 (CHF)的临床疗效。方法 :选取 80例CHF患者 ,随机分为治疗组和对照组各40例 ,对照组予血管紧张素转化酶抑制剂 (ACEI)、利尿剂、血管紧张素受体拮抗剂 (ARB)、硝酸盐类及洋地黄等常规治疗 ,治疗组在此基础上加用美托洛尔 6 2 5mg ,bid ,并逐渐加量 ,最大剂量 5 0mg ,bid。观察并比较 2组治疗前后HR ,BP ,心功能及超声心动图 (UCG)变化。结果 :治疗组和对照组治疗后心功能改善、左心室射血分数 (LVEF)提高、心脏缩小 ,与治疗前比较 ,P <0 0 5。治疗后 2组间比较 ,治疗组UCG各参数值与对照组比较均有显著性差异 (P <0 0 5 ) ,且治疗组的总有效率 (87 5 %) ,高于对照组 (77 5 %) ,且无明显不良反应发生。结论 :美托洛尔可有效地治疗CHF患者。在常规治疗基础上 ,合用美托洛尔可提高治疗CHF的疗效。

AIM: To investigate the clinical effect of metoprolol in the treatment of chronic heart failure (CHF). METHODS: Eighty patients with CHF were allocated randomly and evenly into treatment group and control group. The patients of control group received the routine treatment with angiotensin converting enzyme inhibitors (ACEI), diuretic, angiotensin Ⅱ receptor blocker (ARB), nitrate and digitora, etc.. The treatment group was added with metoprolol 6.25 mg, bid, on the foundation of the routine treatment, and increasing dosage gradually, with the max of 50 mg, bid. The varieties of heart rate, blood pressure, cardiac function and ultrasonic cardiograph (UCG) of 2 groups were compared before and after treatment. RESULTS: The patients of control group were improved in cardiac function with left ventricular ejection fraction (LVEF) rising, and the heart size decreased as compared with before treatment (P<0.05). Furthermore, the treatment group gained such effect (P<0.01) and even more excellent with no obvious adverse drug reaction. CONCLUSION: Metoprolol can be effectively used to treat patients with CHF.