藻酸双酯钠对2型糖尿病血脂异常患者血脂及胰岛素抵抗的影响

Effect of polysaccharide sulfate on insulin-resistance in treatment of type 2 diabetes mellitus and hyperlipidemia

目的 :观察藻酸双酯钠 (PSS)对 2型糖尿病伴高脂血症患者的调脂作用及其对胰岛素抵抗的影响。方法 :采用自身对照方法对 6 2例 2型糖尿病高脂血症患者使用PSS 6 0 0mg·d-1治疗 12wk ,比较治疗前后的血脂、空腹胰岛素敏感指数 (ISI)、体重指数 (BMI)及糖化血红蛋白Alc(HbAlc)的变化。结果 :与治疗前比较 ,PSS治疗 12wk后 ,总胆固醇 (TC)、低密度脂蛋白 胆固醇 (LDL C)和三酰甘油 (TG)分别下降 2 7 88%,34 75 %和 2 9 6 4%(P <0 0 1) ,高密度脂蛋白 胆固醇 (HDL C)上升 2 6 88%(P <0 0 1) ;ISI明显上升 (P <0 0 1) ;BMI下降 (P <0 0 5 ) ;HbAlc明显下降 (P <0 0 1)。结论 :PPS能明显改善 2型糖尿病高脂血症患者的脂代谢异常 ,改善胰岛素抵抗。

AIM: To investigate the effect of polysaccharide sulfate (PSS) on insulin-resistance in the treatment of diabetes mellitus type 2 (2DM) and hyperlipidemia. METHODS: All 62 patients were treated with PSS 600 mg per day for 12 wk and to compare the levels of blood lipids, fasting blood glucose, insulin, insulin sensitivity index (ISI) and body mass index (BMI) with the baseline. RESULTS: Comparing with baseline data, the TC, LDL-C and TG were decreased by 27.88%, 34.75% and 29.64% respectively (all P<0.01); HDL-C was increased by 26.88% (P<0.01), BMI was decreased (P<0.05) with ISI increased remarkably (P<0.01). The percentage of gluco-hemoglobin Alc (HbAlc) which reflect weather 2DM be under good control was lowered (P<0.01). CONCLUSION: PSS can be used to correct the abnormal lipids metablism and improve insulin-resistance in the treatment of 2 DM patients with hyperlipidemia.