宁波市1988～2001年麻疹疫苗效力评价

Assessment for the Effect of Measles Vaccine in Ningbo City from 1988 to 2001

目的 了解麻疹减毒活疫苗 (MV)的效价在我市冷链系统各环节中的变化 ,评价我市计免冷链系统及麻疹疫苗管理质量。方法 于 1988～ 2 0 0 1年对MV效价进行常规跟踪监测 ,在冷链不同环节共检测麻疹疫苗 10 9份。结果 麻疹疫苗效价均值为 2 5 87± 0 2 96logTCID50 /0 1ml,疫苗质量总合格率达 71 5 6% (合格滴度为≥ 2 5logTCID50 /0 1ml) ,本中心冷库疫苗平均滴度与冷链终端 (接种点 )疫苗无明显差异 (t=0 63 1,P =0 5 3 0 )。结论 不同年度疫苗平均滴度呈上升趋势 ,我市在麻疹疫苗贮存、运输、接种等各环节冷链系统管理总体良好。

Objective To analyze the changing effect of the measles toxic-reducing vaccine in cold chain system, and then to assess the management quality of cold chain system and measles vaccine(MV) in Ningbo. Methods 109 MV samples were acquired during the routine monitoring of MV effect in the different links of the cold chain from 1988 to 2001. Results The average titer of MV was 2 587±0 296logTCID 50 /0 1ml. 71 56% of the vaccines reached the qualified titer, which was over 2 5 logTCID 50 /0 1ml.There was no significantly difference between the average titer of MV in the cold storehouse of our center and that in the vaccinating place (t=0 631,P=0 530).Conclusions The cold chain system during storage, transportation and vaccination is well managed in Ningbo.