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钠碘转运体在治疗甲状腺恶性肿瘤中的作用 被引量：4

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摘要 大多数恶性甲状腺肿瘤摄取碘的能力显著降低。钠碘转运体 (NIS)是一种能介导碘向细胞内转运的膜蛋白 ,可以配合放射性碘来治疗肿瘤。目前已经利用转基因技术使不表达或低表达NIS的甲状腺恶性肿瘤细胞表达NIS蛋白。同时发现甲状腺肿瘤细胞摄碘能力的下降不仅与NIS合成的量有关 ,而且与NIS是否能正确锚着密切相关。另外 ,当前研究努力的方向除促进NIS的表达和锚着 。
作者 贾悦 唐伟 刘超
机构地区 南京医科大学第一附属医院内分泌科
出处 《国外医学（内分泌学分册）》 2003年第1期37-39,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家自然科学基金项目 (编号 :39970 35 1)
关键词 钠碘转运体 基因治疗 甲状腺 恶性肿瘤
分类号 R736.105 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Smit J W,Shrodervander E J P,Karperien M,et al.Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS)in a hNIS defective human thyroid carcinoma cell line[].Thyroid.2000
  • 2Tonacchera M,Viacava P,Agretti P,et al.Benign nonfunctioning thyroid adenomas are characterized by a defective targeting to cell membrane or a reduced expression of the sodium iodide symporter protein[].Journal of Clinical Endocrinology and Metabolism.2002
  • 3Russo D,Manole D,Arturi F,et al.Absence of sodium/iodide symporter gene mutations in differentiated human thyroid carcinomas[].Thyroid.2001
  • 4Kohn L D,Suzuki K,Nakazato M,et al.Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte[].Trends in Endocrinology and Metabolism.2001
  • 5Joba W,Spitzweg C,Schriever K,et al.Analysis of human sodium/iodide symporter, thyroid transcription factor-1, and paired-box-protein-8 gene expression in benign thyroid diseases[].Thyroid.1999
  • 6Arturi F,Russo D,Bidart J M,et al.Expression pattern of the pendrin and sodium/iodide symporter genes in human thyroid carcinoma cell lines and human thyroid tumors[].European Journal of Endocrinology.2001
  • 7Boland A,Magnon C,Filetti S,et al.Transposition of the thyroid iodide uptake and organification system in nonthyroid tumor cells by adenoviral vector-mediated gene transfers[].Thyroid.2002
  • 8Suzuki K,Mori A,Saito J,et al.Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene[].The Journal of Endocrinology.1999
  • 9Schmitt T L,Espinoza C R,Loos U.Characterization of a thyroid-specific and cyclic adenosine monophosphate-responsive enhancer far upstream from the human sodium iodide symporter gene[].Thyroid.2002
  • 10Dohan O,De-la-Vieja A,Carrasco N.Molecular study of the sodium-iodide symporter(NIS): a new field in thyroidology[].Trends in Endocrinology and Metabolism.2000

同被引文献26

  • 1Hong-Yan Yin, Xiang Zhou, Hai-Fei Wu, Biao Li, Yi-Fan Zhang.Baculovirus vector-mediated transfer of NIS gene into colon tumor cells for radionuclide therapy[J].World Journal of Gastroenterology,2010,16(42):5367-5374. 被引量：4
  • 2贾悦,刘超,覃又文,刘翠萍,唐伟,袁庆欣,狄福松.维甲酸对乳腺癌细胞MDA-MB453钠碘转运体调控(英文)[J].中国现代医学杂志,2004,14(21):11-14. 被引量：2
  • 3Cho JY, Leveille R,Kao R, et al Hormonal regulation of radioildide uptake activity and Na+/I- symporter expression in mammary glands[J]. J Clin Endocrinol Metab, 2000,85 (8):2936-2943.
  • 4Tazebay UH,Wapnir IL, Levy O, et al. The mammary gland iodide transporter is expressed during lactation and in breast cancer[J]. Nat Med, 2000, 6(8) :871-878.
  • 5Perron B, Rodriguez AM, Leblanc G, et al. Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues[J]. J Endocrinol, 2001,170(1) :185-196.
  • 6Tesarova P, Kvasnicka J, Umlaufova A, et al. Soluble TNF and IL-2 receptors in patients with breast cancer[J]. Med Sci Monit, 2000, 6(4):661-667.
  • 7Ruiz- Ruiz C, Munoz- Pinedo C, Lopez- Rivas A. Interferongamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program[J]. Cancer Res, 2000,60(20) :5673-5680.
  • 8Badache A , Hynes NE . Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop,increases migration of T47D breast cancer cells [J]. Cancer Res, 2001,61(1) :383-391.
  • 9Dohan O,De la Vieja A,Paroder V,et al. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance[J]. Endocr Rev, 2003,24 (1) :48-77.
  • 10Cho JY, Leveille R, Kao R, et al. Hormonal regulation of radioiodide uptake activity and Na +/I-symporter expression in mammary glands. J Clin Endocrinol Metab 2000; 85 (8): 2936-43

引证文献4

二级引证文献9

国外医学（内分泌学分册）
2003年 第1期

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