期刊文献+

一种基于能量的RNA二级结构预测的动态划分算法 被引量:2

AN ENERGY BASED DYNAMIC PATITIONING ALGORITYM FOR RNA SECONDARY STRUCTURE PREDICTION
下载PDF
导出
摘要 预测单链RNA分子序列的二级结构是计算生物学中的一个重要内容.本文基于RNA分子结构的稳定性原理.提出了一种预测RNA二级结构的新算法——基于能量的动态划分算法.该算法的空间复杂度仅为O(n),时间复杂度近似为O(n2·logn),且预测结构有较好的精度. Predicting of RNA secondary structure from linear RNA sequence is an important content in computational biology. Based on the structural stablity principle of RNA molecules, a new prediction algorithm-energy based dynamic patitioning algorithm for RNA secondary structure is presented. The space complexity of the algorithm is only O(n) while the time complexity approximates to O(n2 ?logn).
出处 《数学杂志》 CSCD 北大核心 2003年第1期43-48,共6页 Journal of Mathematics
基金 武汉大学自强创新科研基金资助项目
关键词 能量 RNA 二级结构 预测 动态划分算法 茎区 自由能 RNA secondary structure dynamic patitioning algorithm stem free energy
  • 相关文献

参考文献9

  • 1Nussinov. R & Jacobson AB. Fast algorithm for predicting the secondary structure of single strand RNA [J]. Proc Natl Acid Sci USA. 1980, 77: 6309~6313.
  • 2Zuker M. Optimal computer folding of large RNA sequence using thermodynamics and auxiliary information[J]. Nucl. Acid Res. 1981, 9:133~148.
  • 3J. A. Jaeger, D. H. Turner & M. Zuker. Improved prediction of secondary structure for RNA[J].Proc Natl Acid Sci USA. 1989, 86: 7706~7710.
  • 4David H. Expanded Sequence Dependence of Thermodynamic Parameter Improves Prediction of RNA secondary Structure[J]. JMB. 1999, 288: 911~940.
  • 5Setubal & Meidanis. Introduction to Computational Molecular Biology[M]. Boston: PWS Publishing Company, 1997. 246~250.
  • 6M. S. Waterman. Introduction to Computational Biology[M]. London: Chapman & Hall, 1995. 334~337.
  • 7李伍举,吴加金.RNA二级结构的预测[J].军事医学科学院院刊,1996,20(4):298-301. 被引量:1
  • 8Sankoff. Simultaneous Solution of the RNA Folding, Alignment and Protosequence Problems[J].SIAM J. Appl. Math. 1985, 45(5): 810~825.
  • 9郑仲承.mRNA 5′端二级结构的预测法[J].生命的化学,2000,20(4):176-178. 被引量:3

二级参考文献4

  • 1Han Y,Nucleic Acids Res,1993年,21卷,1251页
  • 2Le S Y,Nucleic Acids Res,1993年,21卷,2173页
  • 3金哲元,病毒学报,1993年,9卷,1页
  • 4徐炜,病毒学报,1993年,9卷,331页

共引文献2

同被引文献24

  • 1李兢,刘长林,申石虎.关于图的极大独立集的理论及生成方法[J].电子学报,1995,23(8):78-79. 被引量:3
  • 2李伍举,吴加金.基于螺旋区随机堆积的RNA二级结构预测[J].生物物理学报,1996,12(2):213-218. 被引量:15
  • 3Sankoff D, Kruskal J, Mainville S, Cedergren R. Fast algorithms to determine RNA secondary structures containing multiple loops//Sankoff D, Kruskal J. Time Warps, String Edits, and Macro-Molecules : The Theory and Practice of Sequence Comparison. Chapter 3. Reading, MA: Addison- Wesley, 1983
  • 4Nussinov R, Jacobson A B. Fast algorithm for predicting the secondary structure of single strand RNA. Proceedings National Academy of Sciences, 1980, 77(11): 6309-6313
  • 5Zuker M. Optimal computer folding of large RNA sequence using thermodynamics and auxiliary information. Nucleic Acids Research, 1981, 9(1): 133-148
  • 6Searls D. The linguistics of DNA. American Scientist, 1992, 80(4): 579-591
  • 7Searls D. The computational linguistics of biological sequences//Hunter L. Artificial Intelligence and Molecular Biology. Menlo Park, California: AAAI Press, 1993:47-120
  • 8Knudsen B, Hein J. RNA secondary structure prediction using stochastic context free grammars and evolutionary history. Bioinformatics, 1999, 15(6): 446-454
  • 9Li Wu-Ju, Wu Jia-Jin. Prediction of RNA secondary structure based on helical regions distribution. Bioinformatics, 1998,14(8) : 700-706
  • 10Turner D H, Sugimoto N. RNA structure prediction. Annual Review of Biophysics and Biophysical Chemistry, 1988, 17: 167-192

引证文献2

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部