金华佛手醇提取液对小鼠学习记忆的影响

Effect of the Ethanolic Extract of Jinhua Bergamot on Learning Memory of Mice

给小鼠3g/(kg.d)、6g/(kg.d)佛手醇提取液,连续15d,观察小鼠开场行为、学习记忆能力、脑单胺类神经递质(DA、5-HT、NA)含量,实验结果表明:小鼠在新环境中自发活动显著减少,学习记忆能力显著增强,脑内去甲肾上腺素、多巴胺和五羟色胺含量显著提高,金华佛手醇提取液能改善小鼠的学习记忆能力。

To investigate the effect of the ethanolic extract of Jinhua Bergamot on learning memory of mice,mice were kept on the ethanolic extract of Jinhua Bergamot,3g/kg body weight or 6g/kg body weight for 15 days.The behavior of the opening field and the learning memory were observed.The contents of DA,NA and 5-HT in brain were measured.The results showed that compared with the control group:the ethanolic extract of Jinhua Bergamot could obviously decrease spontaneity activity of mice in new environment,obviously improve the learning abilities,markedly increase the contents of DA,NA and 5-HT in brain.The conclusion is that the ethanolic extract of Jinhua Bergamot can improve the learning memory of mice.