脑梗死患者血浆及脑脊液中内皮素含量的变化及其临床意义

Changes and clinical significance of endothelin in plasma and CSF of the patients with cerebral infarction

目的探讨内皮素在脑梗死发病中的作用及其临床意义。方法运用放射免疫方法测定脑梗死患者血浆及脑脊液中内皮素的含量 ,应用SPSS软件包进行统计学分析。结果患者急性期血浆、脑脊液内皮素水平均显著高于对照组。伴高血压的患者急性期血浆内皮素较不伴高血压的患者显著升高 ,而脑脊液水平虽高 ,但没有显著性差异。患者急性期血浆内皮素水平与血脂、纤维蛋白原及血流动力学均无显著相关关系。

Objective To explore the role and significance of endothelin in the pathogenesis of cerebral infarction.Methods Radioimmunoassay was applied to measure the endothelin level of plasma and CSF in patients with cerebral infarction.SPSS was used to perform statistic analysis.Results Endothelin in acute stage of the patients was significantly higher than in control group,which was remarkably increased in patients with hypertension compared with the patients without hypertension.CSF level was high without significance.Endothelin in acute stage of the patients was not significantly correlated with blood lipids,fibrinogen and hemodynamics.Conclusion Endothelin has a special role in the pathogenesis of cerebral infarction.