摘要
目的:确立磁性分离酶免疫测定技术应用于产前筛查时各孕周中位数值,以助于推广应用;并对确诊病例实施终止妊娠手术,提高出生人口质量。方法:采用磁性分离酶免疫测定技术检测3000例孕中期母血清标记物——甲胎蛋白(AFP)、游离β-绒毛促性腺激素(β-hCG),筛查唐氏综合征胎儿。结果:建立了青岛地区孕中期产前筛查各孕周中位数值,其随孕周变化趋势与文献报道一致,用于筛查唐氏综合征检出率75%,假阳性率5.2%,并筛出神经管畸形5例,其他畸形2例。结论:磁性分离酶免疫测定技术可应用于产前筛查。产前筛查有助于降低缺陷儿出生,提高出生人口质量。对于筛查阳性病例应尽量动员其进行产前诊断,以进一步提高产前筛查的意义。
Objective:To determine the median of each gestational week of using magnetic - separated enzyme immunoassay (MEIA) in prenatal screening,Providing evidence in diagnosing to improve the quality of the new born. Methods:MEIA was used to detect the maternal serum markers of 3,000 women with second trimester gestation-a- fetoprotein (AFP) ,free B-chorionic gonadotropin( B- hCG) ,in order to prenatal screen for Down syndrome. Results:The median of each gestation week in second - trimester serum screening in Qingdao had been set up and the changing tendency with gestational age was in accordance with the tendency reported by literatures. The detection rate in screening for Down syndrome was 75% and the false positive rate was 5. 2%. 5 cases suffering from neurotube defect (NTD) and 2 cases of other kind of abnormalities had been screened. Conclusion: MEIA can be used in prenatal screening. Prenatal Screening can be helpful to lower birth defect and improve the quality of the new born. Positive cases in screening should be mobilized to perform prenatal testing in order to further improve the significance of the prenatal screening.
出处
《中国计划生育学杂志》
2003年第1期41-43,共3页
Chinese Journal of Family Planning
基金
青岛市卫生局立项资助课题
关键词
孕中期
检测
母血清标记物
筛查
唐氏综合征
胎儿
Magnetometry Enzyme immunoassav a - fetoprotein B- chorionic gonadtropin