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表皮生长因子受体与应激后急性胃肠道损伤 被引量：4

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摘要 表皮生长因子受体(epidermal growth factor receptor,EGFR)是受体酪氨酸激酶家族中的一员,是c-erbB1/EGFR基因编码的膜蛋白。表皮生长因子相关肽家族在急性胃肠道损伤后的修复过程中起着重要的作用。近来研究表明在应激所致急性胃肠道损伤后的修复过程中,EGFR具有介导产生表皮生长因子相关肽及传递其生物学活性的作用,从而发挥重要的功能。
作者 孙洪伟
机构地区 中国医科大学第二临床学院儿科
出处 《国外医学（儿科学分册）》 2003年第1期44-46,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 表皮生长因子受体 应激 急性胃肠道损伤
分类号 Q516 [生物学—生物化学]
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参考文献18

  • 1Barnard J. Epidermal growth factor receptor blockade: an emerging therapeutic modality in gastroenterology[J]. Gastroenterology, 2001,120(7): 1872-1874.
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同被引文献21

  • 1邬善敏,戴植本.肝硬化患者肝脏表皮生长因子受体的表达及其意义[J].中国组织化学与细胞化学杂志,1997,6(2):41-43. 被引量：4
  • 2严洁,阳仁达,易受乡,常小荣,林亚平.从针刺不同经穴对家兔胃黏膜保护作用探讨多经司控同一脏腑的规律[J].中国针灸,2004,24(8):579-582. 被引量：39
  • 3[1]Barnard J.Epidermal growth factor receptor blockade:an Emer-ging therapeutic modality in gastroenterology[J].Gastroenterology.2001,120(7):1872-1874
  • 4[4]Guth PH,Aures D,Paulsen G.Topical aspirin plus HC1 gastric lesions in the rat.Cytoprotective effect of prostaglandin,cimtidine,and probanthine[J].Gastroenterology,1979,76 (1):88-93
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  • 7Konturek PC,Brzozowski T,Konturek SJ,et al.Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage[J].Eur J Pharmacol,1998,342(1):55-65.
  • 8Guth PH,Aures D,Paulsen G.Topical aspirin plus HCl gastric lesions in the rat.Cytoprotective effect of prostaglandin,cimetidine,and probanthine[J].Gastroenterology,1979,76(1):88-93.
  • 9Konturek PC.Physiological,immunohistochemical and molecular aspects of gastric adaptation to stress,aspirin and to H.pylori-derived gastrotoxins[J].J Physiol Pharmacol,1997,48(1):3-42.
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国外医学（儿科学分册）
2003年 第1期

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